Quantitative imaging of peripheral trabecular bone microarchitecture using MDCT.
Quantitative imaging of peripheral trabecular bone microarchitecture using MDCT.
复制标题
DOI：
10.1002/mp.12632
复制
发表时间：
2018-01
期刊：
影响因子：
3.8
通讯作者：
Saha PK
中科院分区：
文献类型：
--
作者：
Chen C;Zhang X;Guo J;Jin D;Letuchy EM;Burns TL;Levy SM;Hoffman EA;Saha PK
与骨矿物质密度（BMD）降低和微结构变化相关的骨质疏松症使患者骨折的风险增加。现代多排螺旋CT（MDCT）技术，在越来越低的辐射剂量下产生高空间分辨率，正在成为一种可行的骨小梁（Tb）成像方式。CT扫描仪的广泛变化引起了多站点和纵向研究中数据一致性的担忧。进行了全面的尸体研究，以评价MDCT衍生的Tb微结构措施。一个人的试点研究进行比较的连续性Tb的措施估计从两个MDCT扫描仪具有显着不同的图像分辨率功能。使用尸体踝关节标本（n=25）的Micro-CT成像来检查MDCT衍生的Tb微结构测量的有效性。重复扫描再现性MDCT为基础的Tb措施和他们的能力，以预测机械性能进行了检查。为了评估Tb测量的多扫描仪数据连续性，使用Siemens SOMATOM Definition Flash和更高分辨率的Siemens SOMATOM Force扫描仪扫描了20名志愿者（年龄：26.2 ± 4.5岁，10 F）的远端胫骨，扫描之间的平均时间间隔为45天。分析了胫骨远端4%至8%处30%和60%剥离区域内两种扫描仪获得的Tb测量值的相关性。表征骨网络面积密度、板-棒微结构和横骨小梁的基于MDCT的Tb测量值与匹配Tb测量值的金标准micro-CT导出值具有良好的相关性（r ∈ [0.85，0.92]）。然而，其他MDCT衍生的Tb测量表征小梁厚度和分离、侵蚀指数和结构模型指数与它们的micro-CT衍生值产生弱相关性（r < 0.8）。发现大多数MDCT Tb测量是可重复的（ICC ∈ [0.94，0.98]）。Tb板宽度测量显示出与实验屈服应力的强相关性（r = 0.89），而横向小梁测量产生与杨氏模量的最高相关性（r = 0.81）。数据连续性实验表明，尽管两种扫描仪之间的图像分辨率存在显著差异（10% MTF沿着xy平面和z方向-Flash：16.2和17.9 lp/cm; Force：24.8和21.0 lp/cm），但大多数Tb测量值在两种扫描仪估计的值之间具有较高的Pearson相关性（r > 0.95）。观察到骨网络面积密度（r = 0.91）和Tb分离（r = 0.93）测量的相关系数相对较低。大多数MDCT衍生的Tb微结构措施是可重复的，它们的值来自两个扫描仪强烈相互关联，以及与骨强度。本研究强调了MDCT衍生的测量值，这些测量值与micro-CT衍生值相比具有良好的相关性（r ≥ 0.85），最有希望表征骨网络面积密度、板-棒和横向小梁分布。同时，代表骨小梁厚度和分离、侵蚀指数和结构模型指数的其他测量与它们的微CT衍生值产生弱相关性（r < 0.8），未能准确描绘投影的骨小梁微结构特征。从两个扫描仪估计Tb措施的强相关性表明，从不同的扫描仪的图像数据可以成功地用于多站点和纵向研究与线性校准所需的一些措施。总之，现代MDCT扫描仪适用于外周Tb微结构的有效定量成像，如果注意集中在适当的定量度量。
Osteoporosis associated with reduced bone mineral density (BMD) and micro-architectural changes puts patients at an elevated risk of fracture. Modern multi detector-row CT (MDCT) technology, producing high spatial resolution at increasingly lower dose radiation, is emerging as a viable modality for trabecular bone (Tb) imaging. Wide variation in CT scanners raise concerns of data uniformity in multi-site and longitudinal studies. A comprehensive cadaveric study was performed to evaluate MDCT-derived Tb micro-architectural measures. A human pilot study was performed comparing continuity of Tb measures estimated from two MDCT scanners with significantly different image resolution features. Micro-CT imaging of cadaveric ankle specimens (n=25) was used to examine the validity of MDCT-derived Tb micro-architectural measures. Repeat scan reproducibility of MDCT-based Tb measures and their ability to predict mechanical properties were examined. To assess multi-scanner data continuity of Tb measures, the distal tibias of twenty volunteers (age: 26.2 ± 4.5 Y, 10 F) were scanned using the Siemens SOMATOM Definition Flash and the higher resolution Siemens SOMATOM Force scanners with an average 45-day time gap between scans. The correlation of Tb measures derived from the two scanners over 30 and 60% peel regions at the 4 to 8% of distal tibia was analyzed. MDCT-based Tb measures characterizing bone network area density, plate-rod micro-architecture, and transverse trabeculae showed good correlations (r ∈ [0.85, 0.92]) with the gold standard micro-CT derived values of matching Tb measures. However, other MDCT-derived Tb measures characterizing trabecular thickness and separation, erosion index, and structure model index produced weak correlation (r < 0.8) with their micro-CT derived values. Most MDCT Tb measures were found repeatable (ICC ∈ [0.94,0.98]). The Tb plate-width measure showed a strong correlation (r = 0.89) with experimental yield stress, while the transverse trabecular measure produced the highest correlation (r = 0.81) with Young’s modulus. The data-continuity experiment showed that, despite significant differences in image resolution between two scanners (10% MTF along xy-plane and z-direction—Flash: 16.2 and 17.9 lp/cm; Force: 24.8 and 21.0 lp/cm), most Tb measures had high Pearson correlations (r > 0.95) between values estimated from the two scanners. Relatively lower correlation coefficients were observed for the bone network area density (r = 0.91) and Tb separation (r = 0.93) measures. Most MDCT-derived Tb micro-architectural measures are reproducible and their values derived from two scanners strongly correlate with each other as well as with bone strength. This study has highlighted those MDCT-derived measures which show the greatest promise for characterization of bone network area density, plate-rod and transverse trabecular distributions with a good correlation (r ≥ 0.85) compared with their micro-CT derived values. At the same time, other measures representing trabecular thickness and separation, erosion index, and structure model index produced weak correlations (r < 0.8) with their micro-CT derived values, failing to accurately portray the projected trabecular micro-architectural features. Strong correlations of Tb measures estimated from two scanners suggests that image data from different scanners can be used successfully in multi-site and longitudinal studies with linear calibration required for some measures. In summary, modern MDCT scanners are suitable for effective quantitative imaging of peripheral Tb micro-architecture if care is taken to focus on appropriate quantitative metrics.
登录
查看更多内容
影响因子：
2.4
作者：
KEAVENY, TM;BORCHERS, RE;HAYES, WC
通讯作者：
HAYES, WC
影响因子：
6.2
作者：
Khosla, S;Riggs, BL;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
5.8
作者：
Boutroy, S;Bouxsein, ML;Delmas, PD
通讯作者：
Delmas, PD
影响因子：
3.8
作者：
Li, Cheng;Jin, Dakai;Saha, Punam K.
通讯作者：
Saha, Punam K.
影响因子：
6.7
作者：
Newell JD Jr;Fuld MK;Allmendinger T;Sieren JP;Chan KS;Guo J;Hoffman EA
通讯作者：
Hoffman EA