Sexual factors and prostate cancer
Sexual factors and prostate cancer
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DOI：
10.1046/j.1464-410x.2003.04319.x
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发表时间：
2003-08-01
影响因子：
4.5
通讯作者：
Hopper, JL
中科院分区：
文献类型：
--
作者：
Giles, GG;Severi, G;Hopper, JL
为了评估前列腺癌是否可能与激素水平有关，并由此推断，与性活动的差异有关，在一项对诊断时年龄< 70岁的前列腺癌男性和年龄匹配的对照受试者的病例对照研究中，收集了关于性活动两个方面的信息;性伴侣的数量和在30到50岁期间射精的频率。前列腺癌与性伴侣的数量和射精的频率无关。或在24小时内射精次数最多。在第三个十年中，风险与射精次数之间存在负相关趋势（P < 0.01），与第四个或第五个十年的风险无关。在20多岁的男性中，平均每周射精5次或以上的男性与射精次数较少的男性相比，其优势比（95%置信区间）为0.66（0.49-0.87）。射精频率，特别是在成年早期，与前列腺癌的风险呈负相关，因此抑制或减少射精的分子生物学后果值得进一步研究。
To assess whether prostate cancer might be related to hormone levels and, by inference, to differences in sexual activity.In a case-control study of men with prostate cancer aged < 70 years at diagnosis and age-matched control subjects, information was collected on two aspects of sexual activity; the number of sexual partners and the frequency of total ejaculations during the third to fifth decades of life.There was no association of prostate cancer with the number of sexual partners or with the maximum number of ejaculations in 24 h. There was a negative trend (P < 0.01) for the association between risk and number of ejaculations in the third decade, independent of those in the fourth or fifth. Men who averaged five or more ejaculations weekly in their 20s had an odds ratio (95% confidence interval) of 0.66 (0.49-0.87) compared with those who ejaculated less often.The null association with the number of sexual partners argues against infection as a cause of prostate cancer in this population. Ejaculatory frequency, especially in early adult life, is negatively associated with the risk of prostate cancer, and thus the molecular biological consequences of suppressed or diminished ejaculation are worthy of further research.