Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry
Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry
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DOI：
10.1111/resp.12989
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发表时间：
2017-07-01
期刊：
影响因子：
6.9
通讯作者：
Corte, Tamera J.
中科院分区：
文献类型：
--
作者：
Glaspole, Ian N.;Chapman, Sally A.;Corte, Tamera J.
背景和目的分析特发性肺纤维化（IPF）患者肺生理功能损害恶化对生活质量影响的研究仅限于单中心或高度选择的试验人群。本研究的目的是确定基线和纵向健康相关的生活质量（HRQoL）的主要决定因素在一个大的IPF population.MethodsWe使用澳大利亚IPF登记研究HRQoL之间的关系，测量使用圣乔治呼吸问卷（SGRQ），和人口统计学特征，生理特征，合并症和症状。进行线性回归分析，以确定基线HRQoL的预测因子，线性混合模型分析，以确定时间和用力肺活量（FVC）对SGRQ和考克斯比例风险回归的影响，检查HRQoL和全因mortals.ResultsBaseline数据从516例患者（347男性，平均（SD）年龄：71.38.6岁）之间的关系。单因素分析显示HRQoL与人口统计学、临床和生理特征之间存在显著相关性。然而，多变量分析表明，SGRQ和呼吸困难之间存在独立关联（加州圣地亚哥大学呼吸急促问卷（UCSD-SOBQ）; R-2 = 0.71，P
Background and objectiveStudies analysing the effect of worsening pulmonary physiological impairment in idiopathic pulmonary fibrosis (IPF) with respect to quality of life have been limited to single centres or highly selected trial populations. The aim of this study was to determine the principal determinants of baseline and longitudinal health-related quality of life (HRQoL) in a large unselected IPF population.MethodsWe used the Australian IPF Registry to examine the relationship between HRQoL, measured using the St George Respiratory Questionnaire (SGRQ), and demographic features, physiological features, co-morbidities and symptoms. Linear regression analysis was performed to identify predictors of baseline HRQoL, linear mixed model analysis to determine the effect of time and forced vital capacity (FVC) on SGRQ and Cox proportional hazards regression to examine the relationship between HRQoL and all-cause mortality.ResultsBaseline data from 516 patients were available (347 males; mean (SD) age: 71.38.6years). Univariate analysis showed significant associations between HRQoL and demographic, clinical and physiological features. However, multivariate analysis demonstrated independent associations only between SGRQ and dyspnoea (University of California San Diego Shortness of Breathlessness Questionnaire (UCSD-SOBQ); R-2 = 0.71, P