Ring-Opening Polymerization of N-Carboxyanhydride-Induced Self-Assembly for Fabricating Biodegradable Polymer Vesicles
Ring-Opening Polymerization of N-Carboxyanhydride-Induced Self-Assembly for Fabricating Biodegradable Polymer Vesicles
复制标题
N-羧酸酐诱导自组装开环聚合制备可生物降解聚合物囊泡
DOI：
10.1021/acsmacrolett.9b00606
复制
发表时间：
2019-10-01
影响因子：
7.015
通讯作者：
Du, Jianzhong
中科院分区：
文献类型：
--
作者：
Jiang, Jinhui;Zhang, Xinyue;Du, Jianzhong
聚合诱导的自组装（比萨）被认为是高分子纳米技术中最重要的策略之一，因为它可以在高浓度和大规模下产生广泛的纳米颗粒。然而，由于传统的比萨通常在无氧条件下进行，以提供不可生物降解的聚合物，因此使用可生物降解的产品进行露天比萨仍然是一个复杂的挑战。为了应对上述挑战，我们提出了一种方便的一锅开放式空气开环聚合（ROP）的N-羧基酸酐（NCA）诱导的自组装（NCA-PISA）在10摄氏度，而不需要脱气，加热，催化剂，或链转移剂。纳米粒子的形貌取决于引发剂与单体的比例和固含量。当比例为1：20，固含量为20%时，可以制备聚合物囊泡。总的来说，这个多功能的一锅NCA-PISA提供了一个在空气中轻松制造可生物降解纳米颗粒的洞察力。
Polymerization-induced self-assembly (PISA) is regarded as one of the most important strategies in macromolecular nanotechnology, as it can create a wide range of nanoparticles at high concentrations and on a large scale. However, open-to-air PISA with biodegradable product is still a complicated challenge, as traditional PISA is usually carried out under oxygen-free conditions to afford nonbiodegradable polymers. To meet the above challenges, we propose a convenient one-pot open-to-air ring-opening polymerization (ROP) of N-carboxyanhydride (NCA)-induced self-assembly (NCA-PISA) at 10 degrees C, without the need for degassing, heating, catalysts, or chain transfer agents. The morphologies of nanoparticles depend on the ratio of the initiator to the monomer and the solid content. Polymer vesicles can be fabricated when the ratio and the solid content are 1:20 and 20%, respectively. Overall, this versatile one-pot NCA-PISA provides an insight into facilely fabricating biodegradable nanoparticles in air.