ACID-BASE TOLERANCE OF THE CORNEA
ACID-BASE TOLERANCE OF THE CORNEA
复制标题
角膜的酸碱耐受性
DOI：
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发表时间：
1944
期刊：
影响因子：
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通讯作者：
H. Herrmann
中科院分区：
文献类型：
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作者：
J. Friedenwald;W. Hughes;H. Herrmann
目前的调查是初步的机制，酸和碱损害角膜的研究。以前在这一领域的工作一直相对缺乏定量分析。我们认为，严格解决这一问题的先决条件是：（1）利用由简单酸、碱或缓冲物质组成的已知等渗溶液;（2）将渗透的物理因素与我们主要感兴趣的纯化学效应分离开来，（3）精心设计了一种数值方法来评估所产生的反应的剧烈程度，以便产生可用于统计学和图形学研究的数据。使用的方法和材料溶液。- 为了使缓冲溶液在所研究的整个pH范围内具有基本上相同的分子组成，我们使用了以下溶液，其类似于Teorell描述的溶液。
The present investigation is preliminary to a study of the mechanisms by which acids and alkalis damage the cornea. Previous work in this field has been relatively devoid of quantitative analysis. We feel that the prerequisites of a rigorous approach to this problem are: (1) the utilization of isotonic solutions of knownphcomposed of simple acids, alkalis or buffer substances; (2) the separation of the physical factors of penetration from those purely chemical effects in which we are primarily interested, and (3) the elaboration of a numerical method of evaluating the severity of the reaction produced, so as to yield data which may be studied statistically and graphically. METHODS AND MATERIAL Solutions Used. —In order to have a buffer solution with essentially the same molecular composition over the entire range ofphstudied, we have used the following solution, which is similar to that described by Teorell