TRYPANOSOMA-EQUIPERDUM - STUDY ON ANTIGENIC VARIATIONS IN EXPERIMENTAL TRYPANSOMIASIS OF RABBITS
TRYPANOSOMA-EQUIPERDUM - STUDY ON ANTIGENIC VARIATIONS IN EXPERIMENTAL TRYPANSOMIASIS OF RABBITS
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DOI：
10.1016/0014-4894(77)90055-8
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发表时间：
1977-01-01
影响因子：
2.1
通讯作者：
MATTERN, P
中科院分区：
文献类型：
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作者：
CAPBERN, A;GIROUD, C;MATTERN, P
对感染同一毒株的抗原性不同克隆的 11 只兔子研究了马鞭草的抗原变异。在这项工作中，通过小鼠接种和克隆分离出了 101 种血清型。制备相应的免疫血清。分离相应类型寄生虫后3-5天测定兔子体内的凝集抗体。血清型出现的顺序是从兔血清中识别出同源抗体的日期揭示的。每只兔子中产生的第一个血清型始终与接种的克隆相对应。在感染不同克隆的兔子中，产生的第一个变体始终属于 BoTat-1 型，被认为是该菌株的基本类型。 3周内，所有兔子以相当恒定的顺序连续发展出一系列早期变异。很难识别后来血清型出现的顺序。这些变异的起源尚不清楚。
The antigenic variations of T. equiperdum were studied on 11 rabbits infected with antigenically different clones derived from the same strain. During this work 101 serotypes were isolated by inoculation in mice and cloning. The corresponding immune sera were prepared. The agglutinating antibodies were determined in the rabbits 3-5 days after isolation of the corresponding type of parasite. The sequence of appearance of serotypes was revealed from the dates on which the homologous antibodies were recognized in the rabbit sera. The 1st serotype developed in each rabbit corresponded always to the inoculated clone. In rabbits infested with a different clone, the 1st variant that developed always belonged to the type BoTat-1, considered the base type of the strain. Within 3 wk there was successive development of a series of early variants in all the rabbits, in a fairly constant order. It was difficult to recognize an order in the sequence of appearance of later serotypes. The origin of these variations is unclear.