The impact of internalizing symptoms on autistic traits in adolescents with restrictive anorexia nervosa.
The impact of internalizing symptoms on autistic traits in adolescents with restrictive anorexia nervosa.
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DOI：
10.2147/ndt.s73235
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发表时间：
2015
影响因子：
3.2
通讯作者：
Muratori F
中科院分区：
文献类型：
--
作者：
Calderoni S;Fantozzi P;Balboni G;Pagni V;Franzoni E;Apicella F;Narzisi A;Maestro S;Muratori F
虽然以前的研究表明，限制性神经性失语症（AN-R）和自闭症特征之间的正相关，这种关联的精神内化共病的潜在干扰尚未得到充分的调查。本研究的目的是探讨青少年（年龄范围：11.7-17.2岁）AN-R的自闭症特征和内在精神病理学。将25例转诊至两家三级医院的患者与一个大型对照组（N=170）进行比较，年龄和性别无差异。AN-R患者和对照组填写了评估自闭症特征（自闭症谱系商[AQ]），精神病理学（青年自我报告[YSR] 11-18）和饮食模式（饮食态度测试[EAT]）的工具。为了解开可能的中介作用的内化症状对自闭症的特质，两个独立的控制组（称为真和假健康对照，均由25个饮食问题的参与者组成）来自整个控制组的基础上存在或不存在的内化问题的YSR。AN-R患者的AQ评分显著高于整个对照组和无内化问题的对照组（True HC），但当仅考虑有内化问题的对照组（False HC）时，这些差异消失。AN-R个体的自闭症特征可能被高估，部分原因可能是受调查患者的共病内化症状。
Although previous studies indicated a positive association between restrictive anorexia-nervosa (AN-R) and autistic traits, the potential interference of psychiatric internalizing comorbidity on this association is not yet fully investigated. The aim of this study was to explore autistic traits and internalizing psychopathology in adolescents (age range: 11.7–17.2 years) with AN-R. Twenty-five patients referred to two tertiary-care hospitals were compared to a large control group (N=170) with no differences in age and sex. AN-R patients and controls filled out instruments assessing autistic traits (autism spectrum quotient [AQ]), psychopathology (youth self-report [YSR] 11–18), and eating patterns (eating attitude test [EAT]). In order to disentangle the possible mediating role of internalizing symptoms on autistic traits, two separate control groups (called True and False healthy control, both composed of 25 eating-problem-free participants) were derived from the whole control group on the basis of the presence or absence of internalizing problems in the YSR. AN-R patients scored significantly higher on AQ compared to the whole control group and to controls without internalizing problems (True HC), but these differences disappeared when only controls with internalizing problems (False HC) were considered. Autistic traits in AN-R individuals may have been overestimated and may partly be due to comorbid internalizing symptoms in investigated patients.