T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis
T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis
复制标题
DOI：
10.1002/ana.25019
复制
发表时间：
2017-10-01
影响因子：
11.2
通讯作者：
Trapp, Bruce D.
中科院分区：
文献类型：
--
作者：
Nakamura, Kunio;Chen, Jacqueline T.;Trapp, Bruce D.
检测多发性硬化症（MS）患者的皮质脱髓鞘是困难的。使用磁共振成像（MRI），T1加权（T1 w）和T2加权（T2 w）图像的比率图可能对皮质髓鞘水平敏感。在这项MRI-组织学研究中，在3 T MRI机器上从6具MS尸体获得死后原位扫描。免疫细胞化学用于关联髓鞘状态和皮质T1 w/T2 w的措施。结果表明，脱髓鞘皮质与有髓鞘皮质的T1 w/T2 w值有显著性差异（P < 0.001）。T1 w/T2 w比值图可能是评估皮质脱髓鞘相对简单、临床可行的方法。神经学年鉴2017;82：635-639
Detecting cortical demyelination in patients with multiple sclerosis (MS) is difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted (T1w) and T2-weighted (T2w) images may be sensitive to cortical myelin levels. In this MRI-histological study, postmortem in situ scans were acquired from 6 cadavers with MS on a 3T MRI machine. Immunocytochemistry was used to correlate myelin status and cortical T1w/T2w measures. The results showed that the T1w/T2w values significantly differed between demyelinated and myelinated cortex (p < 0.001). The T1w/T2w ratio maps may be a relatively simple, clinically feasible method to assess cortical demyelination. Ann Neurol 2017;82:635-639