The effects of pyronaridine on the morphology of Plasmodium falciparum in Aotus trivirgatus
The effects of pyronaridine on the morphology of Plasmodium falciparum in Aotus trivirgatus
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DOI：
10.4269/ajtmh.1996.55.223
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发表时间：
1996-08-01
影响因子：
3.3
通讯作者：
Suzuki, M
中科院分区：
文献类型：
--
作者：
Kawai, S;Kano, S;Suzuki, M
本文报道咯萘啶对一只严重感染恶性疟原虫的猫头鹰猴（Aotus trivirgatus）的形态学的影响。咯萘啶给药后30分钟，晚期滋养体和滋养体已出现明显的形态学变化。超微结构观察表明，最早和最明显的变化发生在食物空泡咯萘啶。食物泡中最显著的变化是未消化的内吞囊泡的出现，在液泡空间中被单膜包围。这些研究结果表明，空泡降解抑制咯萘啶，未消化的内吞囊泡内积累寄生虫的食物空泡损害血红蛋白变性。因此，咯萘啶似乎干扰寄生消化系统。
The effects of pyronaridine on the morphology of Plasmodium falciparum were studied in an infected owl monkey (Aotus trivirgatus) that was severely ill with a parasitemia of 28%. Thirty minutes after pyronaridine administration, distinct morphologic changes were already present in late trophozoites and schizonts. Ultrastructural observations revealed that the earliest and most distinct changes induced by pyronaridine occurred in food vacuoles. The most striking change in food vacuoles was the appearance of undigested endocytic vesicles surrounded by a single membrane in the vacuolar space. These findings suggest that vacuolar degradation is inhibited by pyronaridine, and that undigested endocytic vesicles accumulate inside parasite food vacuoles impairing hemoglobin degeneration. Thus, pyronaridine appears to interfere with the parasitic digestive system.