Novel sulfonated hydrogel composite with the ability to inhibit proteases and bacterial growth
Novel sulfonated hydrogel composite with the ability to inhibit proteases and bacterial growth
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DOI：
10.1002/jbm.a.30440
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发表时间：
2006-01-01
影响因子：
4.9
通讯作者：
Yager, DR
中科院分区：
文献类型：
--
作者：
Vachon, DJ;Yager, DR
人们对开发具有除为伤口提供物理保护和最佳湿度环境之外的功能的伤口敷料越来越感兴趣。为此，开发了一种基于磺化三嵌段聚合物的新型敷料材料。这种多功能聚合物具有离子交换能力，能够结合和控制释放各种治疗剂。该磺化聚合物提供了优于用作伤口敷料的现有商业水凝胶的几个优点。这些包括（1）与磺化水平成比例的亲水性，（2）容易制备织物支撑的敷料（例如，聚酯、棉、尼龙），（3）水合时材料的优异机械完整性，（4）对各种化学物质的稳定性，和（5）对各种灭菌方法的稳定性。在这项研究中，将聚合物涂覆到聚酯织物上，然后通过离子交换进行改性以制备钠盐、银盐或多西环素盐。然后评价这些磺化三嵌段聚合物制剂螯合嗜中性粒细胞蛋白酶、弹性蛋白酶和胶原酶-2（MMP 8）的能力。发现几种制剂螯合显著量的弹性蛋白酶或胶原酶。经证明，这些制剂与目前市售的具有蛋白酶抑制能力的市售敷料进行了对比试验。在相同条件下，实验敷料在抑制MMP-8和弹性蛋白酶方面在统计学上上级市售敷料。(c)2005 Wiley Periodicals，Inc.
There is a growing interest in the development of wound dressings that possess functionality beyond providing physical protection and an optimal moisture environment for the wound. To this end, a novel dressing material based on a sulfonated triblock polymer has been developed. This versatile polymer possesses an ion-exchange capability that is amenable to binding and controlled release of a variety of therapeutic agents. This sulfonated polymer offers several advantages over existing commercial hydrogels used as wound dressings. These include (1) hydrophilicity that is proportional to sulfonation level, (2) easy preparation of fabric supported dressings (e.g., polyester, cotton, nylon), (3) excellent mechanical integrity of the materials when hydrated, (4) stability to a variety of chemistries, and (5) stability to a variety of sterilization methodologies. In this study, polymer was coated onto a polyester fabric and then modified by ion exchange to prepare the sodium, silver, or doxycycline salts. These sulfonated triblock polymer formulations were then evaluated for their capacity to sequester the neutrophil proteases, elastase, and collagenase-2 (MMP8). Several of the formulations were found to sequester significant amounts of either elastase or collagenase. These formulations were demonstrated to be tested against a commercially available dressing that is currently marketed for its protease-inhibiting capability. The experimental dressing was statistically superior to the commercial dressing at inhibiting MMP-8 and elastase under the same conditions. (c) 2005 Wiley Periodicals, Inc.