Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin
Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin
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DOI：
10.1080/07357900801954210
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Rajeswari, Moganty R.
中科院分区：
文献类型：
--
作者：
Sharma, Ashok;Ray, Ruma;Rajeswari, Moganty R.
高迁移率族B组(HMGB)染色体蛋白在皮肤鳞状细胞癌的不同阶段均有表达，在肿瘤和炎症中起重要作用。通过组织病理学、BrdU法、免疫组织化学、Western印迹和RT-PCR等方法分析结果表明，在肿瘤形成的早期阶段，HMGB(B1、B2)的表达仅上调约20%。然而，晚期(12周)肿瘤患者的HMG水平显著升高(80%)。利用皮肤癌模型，我们证明了高水平的HMGB与肿瘤变化的程度直接相关，并且HMGB似乎是促进细胞分化、肿瘤进展和转移侵袭的有效刺激因素。
High mobility group B (HMGB) chromosomal proteins, which plays important role in cancer and inflammation, were followed at various stages of the squamous cell carcinoma of skin. Present results were analyzed by histopathology, BrdU assay, immunohistochemistry, western blot and RT-PCR, which indicate that at early stages of tumorigenesis, expression of HMGB (B1, B2), raised only by about 20%. However, the advanced (12 weeks) tumors showed significant (80%) increase in HMG levels. Using skin cancer model, we demonstrated that high levels of HMGB directly correlate with the extent of neoplastic changes, and it appears that HMGB is an effective stimulus for cell differentiation, tumor progression, and metastatic invasion.