Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.
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DOI：
10.1016/j.bbrc.2015.05.046
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发表时间：
2015-07
影响因子：
3.1
通讯作者：
Meng Xu;Chengfeng Cai;Xuli Sun;Wanze Chen;Qinxi Li;Huamin Zhou
中科院分区：
文献类型：
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作者：
Meng Xu;Chengfeng Cai;Xuli Sun;Wanze Chen;Qinxi Li;Huamin Zhou
Clnk, as a third member of the Blnk/SLP-76 adapter family, is involved in the positive regulation of immunoreceptor signaling. Here we provide findings that Clnk may be is required for TNF induced cell death, it functions downstream of RIP3 and promotes TNF- induced ROS generation and MLKL tetramer formation and subsequent necrosis of L929 cells. Therefore, Clnk, as an adaptor protein, may take part in the other cellular processes.
