Wall shear stress fixed points in cardiovascular fluid mechanics
Wall shear stress fixed points in cardiovascular fluid mechanics
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DOI：
10.1016/j.jbiomech.2018.03.034
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发表时间：
2018-05-17
影响因子：
2.4
通讯作者：
Shadden, Shawn C.
中科院分区：
文献类型：
--
作者：
Arzani, Amirhossein;Shadden, Shawn C.
复杂的血流在大动脉产生丰富的壁剪切应力（WSS）矢量特征。WSS在血流动力学和各种心血管疾病的生物学之间起着联系作用。WSS在广泛的研究中引起了极大的兴趣，并且是将血流与心血管疾病联系起来的最流行的测量方法。近年来的研究强调了WSS的不同向量特征。然而，WSS矢量场中的不动点问题却没有得到足够的重视。WSS固定点是WSS矢量消失的血管壁上的一个点。本文对WSS定点进行了分类，并对其影响心血管疾病的方面进行了综述。首先，讨论了WSS固定点与远离血管壁的流动拓扑之间的联系。其次，利用拉格朗日WSS结构的最新概念，证明了时间平均WSS固定点在生化质量传递中的潜在作用。最后，提出了简单的措施来量化内皮细胞暴露于WSS固定点。从各种动脉血流应用的例子进行了演示。(C) 2018 Elsevier Ltd.版权所有。
Complex blood flow in large arteries creates rich wall shear stress (WSS) vectorial features. WSS acts as a link between blood flow dynamics and the biology of various cardiovascular diseases. WSS has been of great interest in a wide range of studies and has been the most popular measure to correlate blood flow to cardiovascular disease. Recent studies have emphasized different vectorial features of WSS. However, fixed points in the WSS vector field have not received much attention. A WSS fixed point is a point on the vessel wall where the WSS vector vanishes. In this article, WSS fixed points are classified and the aspects by which they could influence cardiovascular disease are reviewed. First, the connection between WSS fixed points and the flow topology away from the vessel wall is discussed. Second, the potential role of time-averaged WSS fixed points in biochemical mass transport is demonstrated using the recent concept of Lagrangian WSS structures. Finally, simple measures are proposed to quantify the exposure of the endothelial cells to WSS fixed points. Examples from various arterial flow applications are demonstrated. (C) 2018 Elsevier Ltd. All rights reserved.