Cognitive Profiles of Incipient Dementia in the Goteborg MCI Study
Cognitive Profiles of Incipient Dementia in the Goteborg MCI Study
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DOI：
10.1159/000321352
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发表时间：
2010-01-01
影响因子：
2.4
通讯作者：
Wallin, Anders
中科院分区：
文献类型：
--
作者：
Nordlund, Arto;Rolstad, Sindre;Wallin, Anders
目的：研究早期痴呆的哪些认知特征最能预测向阿尔茨海默病（AD）和混合性痴呆(MD)/血管性痴呆（VaD）的转变。方法：260例轻度认知障碍（MCI）患者纳入研究，209例（79%）随访2年。在基线时，研究人员对受试者进行了神经心理学测试，测试内容包括速度/注意力、记忆力、视觉空间、语言和执行功能。结果：2年后，9名受试者被认为是正常的，148名患有静止MCI， 47名（23%）转化为痴呆。20名被诊断为AD， 15名被诊断为MD， 9名被诊断为VaD。其余2例为不明原因痴呆，1例为原发性进行性失语。痴呆症转化者在所有认知领域的损伤比例都很高。早期AD和MD/VaD的特征不同，记忆、视觉空间和语言症状出现在AD之前，执行和速度/注意力症状出现在MD/VaD之前。结论：除了记忆受损外，当领域受损时，转化为痴呆的风险也会增加。早期AD和MD/VaD的表现差异非常明显。考虑到血管组由大多数MD患者组成，差异是令人信服的-血管疾病似乎对认知有重要影响。版权所有：S. Karger AG，巴塞尔
Objective: To study which cognitive profiles of incipient dementia strongest predict the conversion to Alzheimer's disease (AD) and mixed dementia (MD)/vascular dementia (VaD). Methods: 260 subjects with mild cognitive impairment (MCI) were included in the study and 209 (79%) were followed up after 2 years. At baseline, the subjects were assessed with a neuropsychological battery covering the cognitive domains speed/attention, memory, visuospatial, language and executive functions. Results: After 2 years, 9 subjects were considered normal, 148 had stationary MCI and 47 (23%) had converted to dementia. Twenty subjects were diagnosed with AD, 15 with MD and 9 with VaD. The others were 2 with unspecified dementias and 1 with primary progressive aphasia. Dementia converters had a high proportion of impairment in all cognitive domains. The profiles of incipient AD and MD/VaD differed, with memory, visuospatial and language symptoms preceding AD, and executive and speed/attention symptoms preceding MD/VaD. Conclusions: The risk of converting to dementia is increased when domains in addition to memory are impaired. The incipient AD and MD/VaD profiles differed quite clearly. Considering that the vascular group consisted of a majority of patients with MD, the differences are convincing - vascular disease seems to have an essential impact on cognition. Copyright (C) 2010 S. Karger AG, Basel