Preliminary study for prevention of neural adhesion using an absorbable oxidised regenerated cellulose sheet.
Preliminary study for prevention of neural adhesion using an absorbable oxidised regenerated cellulose sheet.
复制标题
DOI：
10.1142/s0218810402000911
复制
发表时间：
2002-07-01
期刊：
影响因子：
--
通讯作者：
Tomita, Katsuro
中科院分区：
文献类型：
--
作者：
Ikeda, Kazuo;Yamauchi, Daisuke;Tomita, Katsuro
本研究的目的是阐明可吸收氧化再生纤维素片(AORCS)预防神经粘连的效果。将兔坐骨神经暴露于股中段，用双极电凝器电凝神经床，建立粘连模型。A组(n=8)，B组(n=8)，C组(n=16)，B组(n=8)。六周后，对每组进行评估。A组神经与神经床粘连，神经内纤维化，而B组粘连和纤维化较少，虽然电生理检查显示有微小差异，但AORCS在组织学研究中明显阻止了粘连。因此，在神经外科手术中，AORCS可能是一种有用的辅助治疗方法。
The purpose of this study was to clarify the effect of an absorbable oxidised regenerated cellulose sheet (AORCS) for prevention of neural adhesion. Rabbit sciatic nerve was exposed at the middle of the thigh and the neural bed was coagulated by a bipolar coagulator to establish an adhesion model. Coagulation only was Group A (n = 8), coagulation and wrapping the sciatic nerve with an AORCS was Group B (n = 8), and an intact nerve was Group C (n = 16). Six weeks later, each group was estimated. Adhesion between the nerve and neural bed, and intraneural fibrosis were seen in Group A. However, there was little adhesion and fibrosis in Group B. Although the electrophysiological study showed a small significant difference, AORCS clearly prevented the adhesion in the histological study. Hence, AORCS might be useful as an additional treatment during nerve surgery.