The Cytotoxic T-Lymphocyte Epitope of the Plasmodium falciparum Circumsporozoite Protein Also Modulates the Efficiency of Receptor-Ligand Interaction with Hepatocytes
The Cytotoxic T-Lymphocyte Epitope of the Plasmodium falciparum Circumsporozoite Protein Also Modulates the Efficiency of Receptor-Ligand Interaction with Hepatocytes
复制标题
恶性疟原虫环子孢子蛋白的细胞毒性 T 淋巴细胞表位还调节受体-配体与肝细胞相互作用的效率
DOI：
10.1128/iai.68.2.740-743.2000
复制
发表时间：
2000
影响因子：
3.1
通讯作者：
T. McCutchan
中科院分区：
文献类型：
--
作者：
D. Rathore;T. McCutchan
疟疾子孢子在感染性叮咬后几分钟内从蚊子唾液腺传播到宿主肝细胞。环子孢子蛋白（CS）覆盖疟原虫子孢子的表面，在这几分钟内靶向宿主肝细胞发挥作用。该蛋白质在抗疟疾疫苗中的潜在重要作用引起了对寄生虫存在的宿主免疫反应和该蛋白质在靶向宿主肝细胞中的实际功能作用的兴趣。在这里，我们表明，该地区的CS已知引发的细胞毒性T淋巴细胞（CTL）反应照射子孢子也有点讽刺的是，介导的受体-配体相互作用的寄生虫入侵的主机。因此，CS的结构代表了潜在的反方向力的平衡。CTL表位的多态性似乎是这种平衡状态的产物，而不是经常描述的“军备竞赛”。关于CTL表位多态性不相容性的理论之间的概念差异可能对疫苗设计具有重要意义。
ABSTRACT Malaria sporozoites are transmitted from the mosquito salivary gland to host hepatocytes within minutes of an infectious bite. The circumsporozoite protein (CS), which covers the surface ofPlasmodium sporozoites, functions during these minutes in the targeting of host liver cells. The protein's potentially important role in an antimalaria vaccine has spawned interest in both the host immune responses to the parasite's presence and the actual functional role of the protein in the targeting of host liver cells. Here we show that the region of CS known to elicit a cytotoxic T-lymphocyte (CTL) response to irradiated sporozoites also, somewhat ironically, mediates the receptor-ligand interaction essential to parasite invasion of the host. Hence, the structure of CS represents a balance of potentially counterdirectional forces. Polymorphism in the CTL epitope appears to be a product of this balanced state as opposed to an “arms race” as it is so often portrayed. The conceptual difference between the theories regarding the maintainance of polymorphism in CTL epitopes may have significant implication for vaccine design.
DOI：
10.1073/pnas.96.4.1615
发表时间：
1999-02
影响因子：
11.1
作者：
Y. Shi;Seyed E. Hasnain;J. Sacci;Brian P. Holloway;Hisashi Fujioka;Nirbhay Kumar;Robert M. Wohlhueter;S. L. Hoffman;William E. Collins;A. Lal
通讯作者：
Y. Shi;Seyed E. Hasnain;J. Sacci;Brian P. Holloway;Hisashi Fujioka;Nirbhay Kumar;Robert M. Wohlhueter;S. L. Hoffman;William E. Collins;A. Lal
疟疾环子孢子蛋白：保守区 I 和 II-plus 与硫酸乙酰肝素中的肝素样寡糖的相互作用。
影响因子：
2.1
作者：
Ying,P;Shakibaei,M;Patankar,MS;Clavijo,P;Beavis,RC;Clark,GF;Frevert,U
通讯作者：
Frevert,U
疟疾寄生虫（疟原虫属）的环子孢子蛋白基因：免疫原性区域正向选择的证据。
影响因子：
3.3
作者：
Hughes,AL
通讯作者：
Hughes,AL