Parallel changes in gene expression in aged human and mouse cortex
Parallel changes in gene expression in aged human and mouse cortex
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DOI：
10.1016/j.neulet.2005.07.042
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发表时间：
2005-12-16
影响因子：
2.5
通讯作者：
Bondy, SC
中科院分区：
文献类型：
--
作者：
Sharman, EH;Sharman, KG;Bondy, SC
The intensity of expression of over 20,000 genes and expressed sequence tags within the cerebral cortex has previously been described for both the human and mouse genomes. In both these species, the degree of expression of a relatively limited number of cortical genes, around 300, is significantly altered during senescence. The extent of similarity between age-related alterations of levels of specific mRNAs in either species has been compared. There is a significant correlation between species in those genes whose expression changes markedly in either direction with aging. This parallel serves to validate the use of mouse strains to study general age-related genetic events associated with aging. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
