Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer
Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer
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DOI：
10.1016/s0304-3835(02)00713-9
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发表时间：
2003-03-31
期刊：
影响因子：
9.7
通讯作者：
Nakano, H
中科院分区：
文献类型：
--
作者：
Fujita, T;Miyamoto, S;Nakano, H
溶血磷脂酸（LPA）受体包括LPA（1）、LPA（2）和LPA（3）介导溶血磷脂酸信号。我们分析了LPA受体，血管内皮生长因子（VEGF）和白细胞介素-8在97例卵巢癌患者从正常卵巢，使用逆转录聚合酶链反应。肺癌组织中LPA 2、LPA 3和VEGF的表达率均显著高于非癌组织（P < 0.05）。肿瘤患者LPA（2）和LPA（3）与VEGF的表达率呈显著相关（γ = 0.617，P < 0.0001; γ = 0.431，P < 0.001）。提示LPA 2和LPA 3可能参与了LPA信号介导的VEGF表达。(C)2003爱思唯尔科学爱尔兰有限公司保留所有权利。
Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain reaction. LPA2, LPA3, and VEGF expression ratios significantly increased in cancer, compared to those in non-cancerous state (P < 0.05). A significant correlation in the kxpression ratios between LPA(2) or LPA(3) and VEGF was found (gamma = 0.617, P < 0.0001; gamma = 0.431, P < 0.001) in patients with cancer. These results suggested that LPA2 and LPA3 may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.