Synthesis and stereochemical assignment of angucycline antibiotic, PD-116740
Synthesis and stereochemical assignment of angucycline antibiotic, PD-116740
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DOI：
10.1246/cl.2008.470
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发表时间：
2008-04-05
影响因子：
1.6
通讯作者：
Suzuki, Keisuke
中科院分区：
文献类型：
--
作者：
Mori, Keiji;Tanaka, Yuuya;Suzuki, Keisuke
首次通过两个关键步骤实现了Pd-116740(2)的全合成和绝对结构归属：1)苯并环丁烯衍生物的热环扩张；2)联芳基二醛的频那醇环化。
The first total synthesis and absolute structure assignment of PD-116740 (2) was achieved by exploiting two key steps: 1) a thermal ring expansion of a benzocyclobutene derivative, and 2) pinacol cyclization of biaryl dialdehyde.