Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: A meta-analysis
Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: A meta-analysis
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DOI：
10.1016/j.gene.2015.03.062
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发表时间：
2015-07-01
期刊：
影响因子：
3.5
通讯作者：
Shi, Jingpu
中科院分区：
文献类型：
--
作者：
Hou, Xiaowen;Chen, Xin;Shi, Jingpu
亚甲基四氢叶酸还原酶（MTHFR）C677 T基因多态性与早发冠心病（PCAD）的关系存在争议。为了探索更精确的估计，在本研究中进行了荟萃分析。检索PubMed、EMBASE、Web of Science、科克伦协作数据库、中国知网、万方数据库、中国生物医药数据库，检索到截至2014年11月的相关研究。荟萃分析由STATA 11.21研究进行，共纳入6912例受试者，包括2972例PCAD患者和3940例对照。合并分析显示MTHFR C677 T基因多态性可能与PCAD相关（a对CC：OR = 1.13，95%CI = 1.01-1.27;显性模型：OR = 1.16，95%CI = 1.04-1.29;隐性模型：OR = 1.19，95%CI = 1.00-1.40;等位基因分析：OR = 1.17，95%CI = 1.01-1.34）。血浆同型半胱氨酸浓度的亚组分析显示同型半胱氨酸>15 μ mol/L的亚组有显著相关性（CI '对CC：OR = 1.44，95%CI = 1.10-1.88; TT对CC：OR = 2.51，95%CI = 1.12-5.63;显性模型：OR = 1.51，95%CI = 1.16-1.96;隐性模型：OR = 1.51，95%CI = 1.16-1.96）OR = 2.33，95% CI = 1.05-5.20;等位基因分析OR = 1.48，95% CI = 1.18-1.87）。按大陆进行的亚组分析显示，亚洲人群中（CT与CC：OR = 1.51，95%CI = 1.23-1.86; IT与CC：OR = 2.81，95%CI = 1.87-4.23;显性模型：OR = 1.65，95%CI = 1.35-2.01;隐性模型：OR = 1.65，95%CI = 1.35-2.01）等位基因分析OR = 1.61，95%CI = 137 ~ 1.89）。通过敏感性分析和发表偏倚结果证明了统计学的稳定性和可靠性。结论：MTHFR C677 T基因多态性可能与PCAD相关。(C)2015 Elsevier B. V.版权所有。
The association between 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and premature coronary artery disease (PCAD) is controversial. To explore a more precise estimation of the association, a meta-analysis was conducted in the present study. The relevant studies were identified by searching PubMed, EMBASE, the Web of Science, Cochrane Collaboration Database, Chinese National Knowledge Infrastructure, Wanfang Database and China Biological Medicine up to November, 2014. The meta-analysis was performed by STATA 11.21 studies with a total of 6912 subjects, including 2972 PCAD patients and 3940 controls. The pooled analysis showed that MTHFR C677T gene polymorphism was probably associated with PCAD (a vs. CC: OR = 1.13, 95% Cl = 1.01-1.27; dominant model: OR = 1.16, 95% Cl = 1.04-1.29; recessive model: OR = 1.19,95% CI = 1.00-1.40; allele analysis: OR = 1.17,95% Cl = 1.01-1.34). Subgroup analysis by plasma homocysteine concentration showed a significant association in the homocysteine >15 mu mol/L subgroup (Cl' vs. CC: OR = 1.44,95% Cl = 1.10-1.88; TT vs. CC: OR = 2.51, 95% Cl = 1.12-5.63; dominant model: OR = 1.51, 95% Cl = 1.16-1.96; recessive model: OR = 2.33, 95% Cl = 1.05-5.20; allele analysis: OR = 1.48, 95% Cl = 1.18-1.87). Subgroup analysis by continent displayed a significant association among the Asian population (CT vs. CC: OR = 1.51,95% Cl = 1.23-1.86; IT vs. CC: OR = 2.81,95% CI = 1.87-4.23; dominant model: OR = 1.65, 95% Cl = 1.35-2.01; recessive model: OR = 2.22, 95% Cl = 1.53-3.21; allele analysis: OR = 1.61,95% Cl = 137-1.89). The statistical stability and reliability was demonstrated by sensitivity analysis and publication bias outcomes. In conclusion, the meta-analysis suggests that MTHFR C677T gene polymorphism may be associated with PCAD. (C) 2015 Elsevier B.V. All rights reserved.