The development of an improved physical surrogate model of the human spinal cord-Tension and transverse compression
The development of an improved physical surrogate model of the human spinal cord-Tension and transverse compression
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DOI：
10.1016/j.jbiomech.2009.01.036
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发表时间：
2009-05-11
影响因子：
2.4
通讯作者：
Cripton, Peter A.
中科院分区：
文献类型：
--
作者：
Kroeker, Shannon G.;Morley, Philip L.;Cripton, Peter A.
为了预防脊髓损伤，优化治疗方法，并更好地了解脊髓病变，如脊髓型颈椎病，脊柱和脊髓之间的相互作用损伤和病理过程中必须了解。脊髓是一种复杂且非常软的组织，在死亡后会迅速改变性质，并且难以建模。我们的目标是开发一种物理替代脊髓，其材料特性与体内人类脊髓密切对应，适用于研究各种损伤条件下的脊髓损伤。从已发表的研究中确定了适当的目标材料特性，并在材料试验机中在单轴拉伸下筛选了几种候选替代材料。QM Skin 30（一种硅橡胶弹性体）被确定为最合适的材料。在单轴拉伸和横向压缩条件下测试了由QM Skin 30制成的脊髓。还在均匀压缩下测试了QM Skin 30的矩形样本。QM Skin 30生产的替代脊髓的拉伸和压缩杨氏模量与体内动物脊髓报告的值（分别为0.25和0.20 MPa）大致匹配。拉伸和压缩杨氏模量和行为的替代脊髓模拟在体脊髓的非线性行为。(C)2009爱思唯尔有限公司保留所有权利。
To prevent spinal cord injury, optimize treatments for it, and better understand spinal cord pathologies such as spondylotic myelopathy, the interaction between the spinal column and the spinal cord during injury and pathology must be understood. The spinal cord is a complex and very soft tissue that changes properties rapidly after death and is difficult to model. Our objective was to develop a physical surrogate spinal cord with material properties closely corresponding to the in vivo human spinal cord that would be suitable for studying spinal cord injury under a variety of injurious conditions. Appropriate target material properties were identified from published studies and several candidate surrogate materials were screened, under uniaxial tension, in a materials testing machine. QM Skin 30, a silicone elastomer, was identified as the most appropriate material. Spinal cords manufactured from QM Skin 30 were tested under uniaxial tension and transverse compression. Rectangular specimens of QM Skin 30 were also tested under uniform compression. QM Skin 30 produced surrogate cords with a Young's modulus in tension and compression approximately matching values reported for in vivo animal spinal cords (0.25 and 0.20 MPa, respectively). The tensile and compressive Young's modulus and the behavior of the surrogate cord simulated the nonlinear behavior of the in vivo spinal cord. (C) 2009 Elsevier Ltd. All rights reserved.