Asymptomatic primary cytomegalovirus infection: Virologic and immunologic features
Asymptomatic primary cytomegalovirus infection: Virologic and immunologic features
复制标题
DOI：
10.1086/314939
复制
发表时间：
1999-09-01
影响因子：
6.4
通讯作者：
Pass, RF
中科院分区：
文献类型：
--
作者：
Zanghellini, F;Boppana, SB;Pass, RF
我们随访了45例血清阴性的青少年巨细胞病毒（CMV）感染情况；6人（5名女性，1名男性）在中位7.5个月后血清转化。所有患者均无症状和体征，感染后2-80周，54例尿液中有32例（59.2%）分离出巨细胞病毒；6个月后Viruria发生率降低。巨细胞病毒唾液3科目隔绝,阴道拭子的2 5和1白细胞(WBC)样本,巨细胞病毒DNA聚合酶链反应检测到的白细胞和等离子体从所有科目测试,与巨细胞病毒DNAemia白细胞样本的比例是75% - -80%的16周内感染、48周后0% - -25%,下降的速率等离子DNAemia分裂到8 - 16个星期,-40%至25%下降随着时间的推移,巨细胞病毒免疫球蛋白抗体,糖蛋白B (gB),中和抗体出现后6 - 8周。淋巴细胞对巨细胞病毒和gB的增殖反应较低，与对照组相比，巨细胞病毒的脱落时间比预期的短。虽然抗体反应迅速而有力，但CMV DNA可以在血液中检测到数月。
We followed 45 seronegative adolescents for acquisition of cytomegalovirus (CMV); 6 (5 female, 1 male) seroconverted after a median of 7.5 months. All were free of signs and symptoms, CMV was isolated from 32 (59.2%) of 54 urines, 2-80 weeks after infection; viruria was less frequent after 6 months. CMV was isolated from saliva of 3 subjects, vaginal swabs of 2 of 5, and 1 white blood cell (WBC) sample, CMV DNA was detected by polymerase chain reaction in WBCs and plasma from all subjects tested, The proportion of WBC samples with CMV DNAemia was 75%-80% within 16 weeks of infection, declining to 0%-25% after 48 weeks, The rate of plasma DNAemia was 25%-40% at 8-16 weeks, declining with time, IgG antibody to CMV, glycoprotein B (gB), and neutralizing antibody were present after 6-8 weeks. Lymphocyte proliferative responses to CMV and to gB were low, compared with those of controls, CMV shedding was of shorter duration than expected. Although antibody response was prompt and vigorous, CMV DNA could be detected in blood for months.