Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products.
Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products.
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固体脂质纳米粒子（SLN/Lipopearls）——一种用于皮肤产品中应用维生素 E 的药物和化妆品载体。
DOI：
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发表时间：
1999
影响因子：
3.9
通讯作者：
S. Gohla
中科院分区：
文献类型：
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作者：
A. Dingler;R. Blum;H. Niehus;R. Müller;S. Gohla
固体脂质纳米粒(SLN，Lipopearls)是由固体脂质高压均质而成的纳米颗粒。在固体脂质基质中加入化学不稳定的活性成分可以防止化学降解，这对维生素E来说是证明的。SLN在水分散液中物理上是稳定的，而且在加入真皮霜后也是如此，光子相关光谱和差示扫描量热仪证明了这一点。电子显微镜和原子力显微镜数据揭示了SLN的球形和颗粒表面的详细结构。超细颗粒形成一层粘附膜，导致皮肤闭塞。剥离测试表明，这种遮盖物促进了维生素E在皮肤中的渗透。除了有效成分的化学稳定、对皮肤的遮挡作用以及随后增强化合物的渗透性外，SLN还具有覆盖不想要的颜色的色素效果，从而提高了客户的审美接受度。
Solid lipid nanoparticles (SLN, Lipopearls) are nanoparticles made from solid lipids by high pressure homogenization. Incorporation of chemically labile active ingredients into the solid lipid matrix protects against chemical degradation, which is shown for vitamin E. The SLN are physically stable in aqueous dispersions and also after incorporation into a dermal cream as proven by photon correlation spectroscopy and differential scanning calorimetry. Electron microscopy and atomic force microscopy data reveal the spherical shape of the SLN and the detailed structure of the particle surface. Ultrafine particles form an adhesive film leading to an occlusive effect on the skin. The occlusion promotes the penetration of vitamin E into the skin, as shown by the stripping test. In addition to chemical stabilization of active ingredients, occlusive effects on the skin and subsequent enhanced penetration of compounds, the SLN also possess a pigment effect covering undesired colours leading to an increased aesthetic acceptance by the customer.