[Interferon-induced retinal changes].
[Interferon-induced retinal changes].
复制标题
[干扰素引起的视网膜变化]。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
M. Shigehira
中科院分区：
文献类型：
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作者：
T. Chuman;N. Nao;A. Sawada;T. Kawano;M. Shigehira
对50例慢性丙型肝炎、慢性乙型肝炎和肾细胞癌患者进行干扰素治疗，检查其视网膜并发症。23例（46%）患者出现视网膜出血或棉絮斑。视网膜出血无棉絮斑14例，棉絮斑无视网膜出血5例，既有出血又有棉絮斑4例。这些发现可能是可逆的。视网膜分支动脉闭塞1例，微动脉瘤1例。视网膜病变患者红细胞计数明显低于无视网膜病变患者（p < 0.05%）。糖尿病、高血压、视网膜动脉硬化和贫血的患者有视网膜病变的风险。
Fifty patients treated with interferon for chronic type C hepatitis, chronic type B hepatitis and renal cell carcinoma were examined for retinal complications. Retinal hemorrhages or cotton wool spots were observed in 23 (46%) of the patients. Retinal hemorrhages without cotton wool spots were found in 14 patients, cotton wool spots without retinal hemorrhages in 5 patients, and both hemorrhages and cotton wool spots in four patients. These findings were potentially reversible. There was one case of branch retinal artery occlusion and one case with microaneurysm. Red blood cell count decreased significantly in the patients with retinopathy compared with those without retinopathy (p < 0.05%). Patients with diabetes, hypertension, retinal arterial sclerosis, and anemia were at risk for retinopathy.