Evaluation of Prognostic Significance of Immunological Cells (Tissue Eosinophil and Mast Cell) Infiltration in Oral Squamous Cell Carcinoma
Evaluation of Prognostic Significance of Immunological Cells (Tissue Eosinophil and Mast Cell) Infiltration in Oral Squamous Cell Carcinoma
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口腔鳞状细胞癌中免疫细胞（组织嗜酸性粒细胞和肥大细胞）浸润的预后意义评估
DOI：
10.4172/1948-5956.1000089
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
V. Wadhwan
中科院分区：
文献类型：
--
作者：
P. Debta;F. Debta;M. Chaudhary;V. Wadhwan
背景：在口腔癌中，人们已经做出了很多努力来预测患者的预后，但对基础细胞生物学的深入了解可能需要取得进展。最近，人们的注意力集中在肿瘤相关组织嗜酸性粒细胞和肥大细胞及其在肿瘤生物学行为中的作用。目的：回顾性研究肿瘤相关组织嗜酸性粒细胞和肥大细胞对口腔鳞状细胞癌（OSCC）预后的影响。材料和方法：对组织病理学诊断的 30 例 OSCC 病例进行至少 3 年的随访。特殊染色剂非常棒，它们使我们能够看到常规 H&E 染色剂无法清晰看到的内容。组织切片用特殊染色剂进行染色，Carbol Chromotrope 用于组织嗜酸性粒细胞染色，甲苯胺蓝用于组织肥大细胞染色。结果：本研究结果表明，OSCC 中组织嗜酸性粒细胞和肥大细胞浸润增加，与良好的预后相关。结论：我们得出结论，组织嗜酸性粒细胞和肥大细胞的浸润是 OSCC 预后良好的指标。因此，嗜酸性粒细胞和肥大细胞的定量评估是口腔鳞癌显微评估中最重要的方面。
Background: In oral carcinoma much effort has been made to predict the prognosis of patients but a sound understanding of underlying cell biology is likely to need progress. Recently, attention has been directed towards tumour associated tissue eosinophils and mast cells and their role in the biologic behavior of tumours. Aim: The retrospective study was used to evaluate the influence of tumour associated tissue eosinophils and mast cells on prognosis of oral squamous cell carcinoma (OSCC). Material and methods: The follow-up, of histopathologically diagnosed thirty cases of OSCC, was carried out for minimum period of 3 years. Special stains are wonderful they allow us to see which we can not see clear with routine H&E stain.Tissue sections were stained with special stains, Carbol Chromotrope for tissue eosinophil and Toluidine blue for tissue mast cell staining. Result: The results of the present study shows that increase infiltration of tissue eosinophils and mast cells in OSCC, associated with favourable prognosis. Conclusion: We concludes that infiltration of tissue eosinophils and mast cells are indicators of favourable prognosis in OSCC. Thus quantitative assessment of eosinophils and mast cells are the most important aspects of the microscopic evaluation of OSCC.
影响因子：
4.7
作者：
Sinnamon, Mark J.;Carter, Kathy J.;Matrisian, Lynn M.
通讯作者：
Matrisian, Lynn M.