A possible link between resveratrol and TGF-β:: Resveratrol induction of TGF-β expression and signaling
A possible link between resveratrol and TGF-β:: Resveratrol induction of TGF-β expression and signaling
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DOI：
10.1016/j.febslet.2008.01.024
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发表时间：
2008-03-05
期刊：
影响因子：
3.5
通讯作者：
Nakao, Atsuhito
中科院分区：
文献类型：
--
作者：
Suenaga, Fumiko;Hatsushika, Kyosuke;Nakao, Atsuhito
白藜芦醇是一种在红色水果的果皮中发现的多酚化合物，具有抗炎、抗氧化和抗增殖的特性。转化生长因子-β（TGF-β）是一种多效性细胞因子，也显示出这些特性。因此，我们假设白藜芦醇和TGF-β之间可能存在功能性联系。本研究报道了白藜芦醇在A549人肺上皮细胞系中以自分泌方式增加TGF-β 2基因的转录，增强TGF-β 2蛋白的产生，并激活Smad信号。因此，白藜芦醇对人类健康的一些有益作用可能部分通过其对TGF-β表达和信号传导的影响来介导。(C)2008年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta 2 gene, enhanced the production of TGF-beta 2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.