Vo2max is associated with ACE genotype in postmenopausal women
Vo2max is associated with ACE genotype in postmenopausal women
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DOI：
10.1152/jappl.1998.85.5.1842
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发表时间：
1998-11-01
影响因子：
3.3
通讯作者：
Moore, GE
中科院分区：
文献类型：
--
作者：
Hagberg, JM;Ferrell, RE;Moore, GE
血管紧张素转换酶(ACE)基因与心血管疾病的各种病理和生理结局及功能之间的关系经常被发现。因此，我们试图确定ACE基因型是否影响具有不同习惯性体力活动水平的绝经后女性的最大氧耗量((V)/点O-2max)和最大运动动力学。年龄、身体成分和习惯性体力活动水平在ACE基因型组之间没有差异。然而，在考虑体力活动水平的影响后，ACE插入/插入(II)基因携带者比ACE缺失/缺失(DD)基因携带者在点O-2max上的V高6.3ml.kg(-1).min(-1)(P<；0.05)。ACE II基因型组与ACE插入/缺失(ID)基因型组相比，O-2max(P<；0，05)增加3.3ml.kg(-1).min(-1)。ACE ID组的Vet，有高于DD型组的趋势，但差异无统计学意义。在考虑了习惯性体力活动水平的影响后，女性(V)对DOT O-2max的变异中，ACE型占12%。不同ACE基因组间(V)/点O-2max的差异是动静脉血氧分压最大差值(a-VDO(2))差异的结果。ACE型占这些女性最大α-VDO(2)变异的17%。最大心输出量指数在不同ACE基因型组之间没有任何差异。因此，在这些女性中，血管紧张素转换酶基因的个体间差异(V)超过点O-2max的很大一部分似乎是由ACE基因决定的。然而，这种差异是最大a-VDO(2)的基因依赖性差异的结果，而不是最大每搏量和最大心输出量的差异。
Relationships have frequently been found between angiotensin-converting enzyme (ACE) genotype and various pathological and physiological cardiovascular outcomes and functions. Thus we sought to determine whether ACE genotype affected maximal O-2 consumption ((V) over dot O-2max) and maximal exercise hemodynamics in postmenopausal women with different habitual physical activity levels. Age, body composition, and habitual physical activity levels did not differ among ACE genotype groups. However, ACE insertion/insertion (II) genotype carriers had a 6.3 ml.kg(-1).min(-1) higher (V) over dot O-2max (P < 0.05) than the ACE deletion/deletion (DD) genotype group after accounting for the effect of physical activity levels. The ACE II genotype group also had a 3.3 ml.kg(-1).min(-1) higher (V) over dot O-2max (P < 0,05) than the ACE insertion/deletion (ID) genotype group. The ACE ID group tended to have a higher Vet,, than the DD genotype group, but the difference was not significant. ACE genotype accounted for 12% of the variation in (V) over dot O-2max,, among women after accounting for the effect of habitual physical activity levels. The entire difference in (V) over dot O-2max,, among ACE genotype groups was the result of differences in maximal arteriovenous O-2 difference (a-vDO(2)). ACE genotype accounted for 17% of the variation in maximal a-vDO(2) in these women. Maximal cardiac output index did not differ whatsoever among ACE genotype groups. Thus it appears that ACE genotype accounts for a significant portion of the interindividual differences in (V) over dot O-2max among these women. However, this difference is the result of genotype-dependent differences in maximal a-vDO(2) and not of maximal stroke volume and maximal cardiac output.