Brief report: Laryngeal transplantation and 40-month follow-up.
Brief report: Laryngeal transplantation and 40-month follow-up.
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DOI：
10.1056/nejm200105313442204
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发表时间：
2001-05-31
影响因子：
158.5
通讯作者：
Mayes, J
中科院分区：
文献类型：
--
作者：
Strome, M;Stein, J;Mayes, J
全喉切除和气管切开术喉完全闭塞与味觉和嗅觉受损、气管和支气管炎的发生率增加、造口结痂、鼻呼吸丧失和听起来像人的声音丧失有关。在治疗喉部已无法修复的损伤的患者时，一个基本的考虑因素是手术的目标是否应该包括喉部置换，以改善患者的生活质量。早期尝试用部分喉移植治疗喉癌时，肿瘤迅速复发，这一结果几乎打消了人们对该手术的兴趣。
Total laryngectomy and total occlusion of the larynx with tracheostomy are associated with an impaired sense of taste and smell, an increased incidence of tracheobronchial infections, stomal encrustations, loss of nasal respiration, and loss of a human-sounding voice. A fundamental consideration in treating a patient whose larynx has been irreparably damaged is whether the goals of surgery should include replacement of the larynx to improve the patient's quality of life. An early attempt to treat laryngeal cancer with a partial laryngeal transplant1was accompanied by rapid recurrence of the tumor, an outcome that quashed interest in the procedure for nearly . . .