Adaptation and validation of the Treatment Burden Questionnaire (TBQ) in English using an internet platform.
Adaptation and validation of the Treatment Burden Questionnaire (TBQ) in English using an internet platform.
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DOI：
10.1186/1741-7015-12-109
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发表时间：
2014-07-02
期刊：
影响因子：
9.3
通讯作者：
Ravaud P
中科院分区：
文献类型：
--
作者：
Tran VT;Harrington M;Montori VM;Barnes C;Wicks P;Ravaud P
治疗负担是指医疗保健对患者施加的工作量及其对生活质量的影响。治疗负担问卷（TBQ）旨在评估不同情况和治疗背景下的治疗负担。在这里，我们的目的是评估英语版本的TBQ的效度和信度，这个量表最初是在法语中开发的。TBQ采用正向倒译法翻译成英文。在一项涉及200名慢性疾病患者的前测中，对措辞和可能缺失的项目进行了评估。使用PatientsLikeMe网站，通过患者网络在线评估仪器的测量特性。采用因子分析法评估问卷的维度结构。通过TBQ总体评分wıth临床变量、Morisky药物依从性量表（MMAS-8）评估的药物依从性、PatientsLikeMe生活质量量表（PLMQOL）评估的生活质量以及患者对其病情和治疗知识的信心来评估结构效度。通过重测法确定信度。在2013年9月至10月期间，共有610名慢性疾病患者完成了TBQ，主要来自美国、英国、加拿大、澳大利亚或新西兰。英语TBQ呈现单维结构，Cronbach α值为0.90。TBQ总体评分与PLMQOL评分呈负相关（rs = - 0.50; p < 0.0001）。低而非中度或高度的药物依从性与高TBQ评分相关（TBQ评分平均[SD] 61.8[30.5]比37.7 [27.5];P < 0.0001）。治疗知识不足组患者的治疗负担高于治疗知识充分组患者（平均±SD TBQ评分62.3±31.3比47.8±30.4,P < 0.0001）和病情（63.0±31.6比49.3±30.7,P < 0.0001）。重测的类内相关系数（n = 282）为0.77 （95% CI 0.70 ~ 0.82）。我们发现英语TBQ在这一人群中是一个可靠的工具，并提供证据支持其用于评估英语国家一种或多种慢性疾病患者治疗负担的结构效度。
Treatment burden refers to the workload imposed by healthcare on patients, and the effect this has on quality of life. The Treatment Burden Questionnaire (TBQ) aims to assess treatment burden in different condition and treatment contexts. Here, we aimed to evaluate the validity and reliability of an English version of the TBQ, a scale that was originally developed in French. The TBQ was translated into English by a forward-backward translation method. Wording and possible missing items were assessed during a pretest involving 200 patients with chronic conditions. Measurement properties of the instrument were assessed online with a patient network, using the PatientsLikeMe website. Dimensional structure of the questionnaire was assessed by factor analysis. Construct validity was assessed by associating TBQ global score wıth clinical variables, adherence to medication assessed by Morisky’s Medication Adherence Scale (MMAS-8), quality of life (QOL) assessed by the PatientsLikeMe Quality of Life Scale (PLMQOL), and patients’ confidence in their knowledge of their conditions and treatments. Reliability was determined by a test–retest method. In total, 610 patients with chronic conditions, mainly from the USA, UK, Canada, Australia, or New Zealand, completed the TBQ between September and October 2013. The English TBQ showed a unidimensional structure with Cronbach α of 0.90. The TBQ global score was negatively correlated with the PLMQOL score (rs = −0.50; p < 0.0001). Low rather than moderate or high adherence to medication was associated with high TBQ score (mean [SD] TBQ score 61.8 [30.5] vs. 37.7 [27.5]; P < 0.0001). The treatment burden was higher for patients who had insufficient knowledge compared with those who had sufficient knowledge about their treatments (mean ± SD TBQ score 62.3 ± 31.3 vs. 47.8 ± 30.4; P < 0.0001) and conditions (63.0 ± 31.6 vs. 49.3 ± 30.7; P < 0.0001). The intraclass correlation coefficient for the retest (n = 282) was 0.77 (95% CI 0.70 to 0.82). We found that the English TBQ is a reliable instrument in this population, and provide evidence supporting the construct validity for its use to assess treatment burden for patients with one or more chronic conditions in English-speaking countries.
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