Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings
Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings
复制标题
DOI：
10.1016/j.nmd.2004.04.007
复制
发表时间：
2004-09-01
影响因子：
2.8
通讯作者：
Levin, LS
中科院分区：
文献类型：
--
作者：
Quinlan, JG;Hahn, HS;Levin, LS
心力衰竭是杜氏肌营养不良症男孩死亡的主要原因。为了确定mdx小鼠的心脏功能是否同样受到干扰，我们进行了小鼠超声心动图和左心导管插入术研究，沿着心脏纤维化的形态学分析。mdx小鼠的连续超声心动图显示了从年轻小鼠的正常心脏功能到成年小鼠的扩张型心肌病的演变。高龄mdx小鼠表现出广泛但斑片状的心室壁纤维化增加。这些结果表明，mdx心脏功能受损比以前认为的更严重，并与Duchenne肌营养不良症的心肌病具有重要的临床特征。(C)2004 Elsevier B.V.保留所有权利。
Heart failure is a major cause of death in boys with Duchenne muscular dystrophy. In order to determine if the cardiac function of the mdx mouse is similarly disturbed, we performed murine echocardiograms and left heart catheterization studies, along with morphometric analysis of cardiac fibrosis. Serial echocardiograms in mdx mice revealed the evolution from normal cardiac function in young mice to a dilated cardiomyopathy in adult mice. Very old mdx mice exhibited a widespread but patchy increase in ventricular wall fibrosis. These results show that the mdx cardiac function is more impaired than was previously thought and shares important clinical features with the cardiomyopathy of Duchenne muscular dystrophy. (C) 2004 Elsevier B.V. All rights reserved.