Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations
Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations
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DOI：
10.1016/j.jneuroim.2006.08.009
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发表时间：
2006-11-01
影响因子：
3.3
通讯作者：
Hillert, Jan
中科院分区：
文献类型：
--
作者：
Lundmark, Frida;Harbo, Hanne F.;Hillert, Jan
我们研究了CD4和LAG3基因的遗传关联，由于它们在多发性硬化（MS）病理中所起的作用，这两个基因是MS很有吸引力的候选基因。我们对一个由920名MS患者和778名对照组成的瑞典病例 - 对照样本进行了CD4基因分型，在初步研究中，三个单核苷酸多态性（SNP）显示与MS显著相关。一个由1720名北欧MS患者和1416名对照组成的独立样本被用于验证CD4中相关的标记，并对先前发现的LAG3基因进行验证性研究。结果显示，包括总共2640名MS患者和2194名对照，CD4和LAG3与MS之间没有显著关联。我们得出结论，就MS的遗传易感性而言，这些基因的重要性较小。（c）2006爱思唯尔公司。保留所有权利。
We have investigated the genetic involvement of the CD4 and the LAG3 genes, two appealing candidates for MS due to their suggested role in MS pathology. We genotyped a Swedish case-control material consisting of 920 MS patients and 778 controls in an initial study of CD4, three SNPs showed a significant association with MS. An independent material consisting of 1720 Nordic MS patients and 1416 controls were used for confirmation of associated markers in CD4 and to do a confirmative study of the LAG3 gene from previous findings. The result, including a total of 2640 MS patients and 2194 controls shows no significant association with CD4 and LAG3 and MS. We conclude that these genes are of minor importance in regard of genetic predisposition to the MS. (c) 2006 Elsevier B.V. All rights reserved.