Different dimensions of the prediction error as a decisive factor for the triggering of the reconsolidation process
Different dimensions of the prediction error as a decisive factor for the triggering of the reconsolidation process
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DOI：
10.1016/j.nlm.2016.10.016
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发表时间：
2016-12-01
影响因子：
2.7
通讯作者：
Pedreira, Maria E.
中科院分区：
文献类型：
--
作者：
Agustina Lopez, M.;Jimena Santos, M.;Pedreira, Maria E.
重新巩固过程是更新巩固记忆的强度和/或内容的机制。预测误差（PE）是预测与当前事件之间的差异。建议将其作为触发重组进程的必要条件。在这里，我们深入分析了 PE 在螃蟹 Neohelice 颗粒联想记忆重建中的作用。条件刺激和非条件刺激（CS-US）之间习得的时间关系之间的不一致足以触发重新巩固过程。此外，经过部分强化训练后，50%的PE开启了通过提醒（包括或不包括美国）来稳定巩固记忆的可能性。此外，在消退训练期间，CS 之间的第一个间隔中的小 PE 足以触发再巩固。总的来说，我们强调了训练历史和不同重新激活可能性之间的关系，以招募负责记忆更新的过程。 (C) 2016 Elsevier Inc. 保留所有权利。
The reconsolidation process is the mechanism by which strength and/or content of consolidated memories are updated. Prediction error (PE) is the difference between the prediction made and current events. It is proposed as a necessary condition to trigger the reconsolidation process. Here we analyzed deeply the role of the PE in the associative memory reconsolidation in the crab Neohelice granulate. An incongruence between the learned temporal relationship between conditioned and unconditioned stimuli (CS-US) was enough to trigger the reconsolidation process. Moreover, after a partial reinforced training, a PE of 50% opened the possibility to labilize the consolidated memory with a reminder which included or not the US. Further, during an extinction training a small PE in the first interval between CSs was enough to trigger reconsolidation. Overall, we highlighted the relation between training history and different reactivation possibilities to recruit the process responsible of memory updating. (C) 2016 Elsevier Inc. All rights reserved.