Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis.
Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis.
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DOI：
10.1038/tp.2016.55
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发表时间：
2016-04-26
影响因子：
6.8
通讯作者：
Law AC
中科院分区：
文献类型：
--
作者：
Lau WK;Leung MK;Lee TM;Law AC
遗忘型轻度认知功能障碍（Amnestic mild cognitive impairment，aMCI）是阿尔茨海默病（Alzheimer's disease，AD）的前驱期。由于目前尚无有效的治疗AD的药物，因此，对aMCI的早期诊断和干预是迫切需要的。aMCI的标准诊断程序主要依赖于主观神经心理学检查，需要经验丰富的临床医生的判断。因此，需要开发其他客观和可靠的aMCI标志物，如神经标志物。先前的神经影像学研究结果显示MCI患者的静息状态活动存在各种异常，但结果不一致。目前的研究提供了一个更新的激活可能性估计荟萃分析的静息态功能磁共振成像（fMRI）数据的aMCI。作者在MEDLINE/PubMed数据库中检索了截至2015年3月发表的关于aMCI的全脑静息状态fMRI研究。我们纳入了21项全脑静息状态fMRI研究，共报告了156个不同的病灶。aMCI患者与对照组相比，持续存在显著的区域静息状态差异，包括后扣带回皮质、右侧角回、右侧海马旁回、左侧梭状回、左侧缘上回和双侧颞中回。我们的研究结果支持这些区域的静息态活动异常可以作为aMCI的神经影像学标志物。
Amnestic mild cognitive impairment (aMCI) is a prodromal stage of Alzheimer's disease (AD). As no effective drug can cure AD, early diagnosis and intervention for aMCI are urgently needed. The standard diagnostic procedure for aMCI primarily relies on subjective neuropsychological examinations that require the judgment of experienced clinicians. The development of other objective and reliable aMCI markers, such as neural markers, is therefore required. Previous neuroimaging findings revealed various abnormalities in resting-state activity in MCI patients, but the findings have been inconsistent. The current study provides an updated activation likelihood estimation meta-analysis of resting-state functional magnetic resonance imaging (fMRI) data on aMCI. The authors searched on the MEDLINE/PubMed databases for whole-brain resting-state fMRI studies on aMCI published until March 2015. We included 21 whole-brain resting-state fMRI studies that reported a total of 156 distinct foci. Significant regional resting-state differences were consistently found in aMCI patients relative to controls, including the posterior cingulate cortex, right angular gyrus, right parahippocampal gyrus, left fusiform gyrus, left supramarginal gyrus and bilateral middle temporal gyri. Our findings support that abnormalities in resting-state activities of these regions may serve as neuroimaging markers for aMCI.