SUPPRESSION OF MYC BY HIGH EXPRESSION OF NMYC IN HUMAN NEURO-BLASTOMA CELLS
SUPPRESSION OF MYC BY HIGH EXPRESSION OF NMYC IN HUMAN NEURO-BLASTOMA CELLS
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DOI：
10.1002/jnr.490240105
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发表时间：
1989-09-01
影响因子：
4.2
通讯作者：
SCHWAB, M
中科院分区：
文献类型：
--
作者：
BREIT, S;SCHWAB, M
MYC基因家族的成员，包括MYC、NMYC和LYMC，已经发现在各种人类癌症中以高水平扩增和表达。我们分析了MYC基因家族的两个成员，NMYC和MYC，在人类和小鼠神经母细胞瘤细胞的表达。当NMYC和MYC共表达时，MYC表达占优势。由于扩增而携带NMYC高表达的细胞缺乏MYC表达。对于神经母细胞瘤细胞也是如此，其中单拷贝NMYC的表达被上调，或者其中通过转染引入了迫使外源NMYC高表达的载体。我们的研究表明在神经母细胞瘤细胞中MYC和NMYC之间存在调节性相互作用。
Members of the MYC gene family, including MYC, NMYC, and LYMC, have been found amplified and expressed at high level in various human cancers. We have analyzed the expression of two members of the MYC gene family, NMYC and MYC, in human and murine neuroblastoma cells. Whenever NMYC and MYC are co-expressed, MYC expression predominates. Cells carrying high expression of NMYC as result of amplification lack MYC expression. The same is true for neuroblastoma cells in which expression of a single-copy NMYC is upregulated or into which a vector forcing high expression of an exogenous NMYC had been introduced by transfection. Our studies indicate a regulatory interaction between MYC and NMYC in neuroblastoma cells.