ABSOLUTE STEREOSTRUCTURES OF ALISMALACTONE 23-ACETATE AND ALISMAKETONE-A 23-ACETATE, NEW SECO-PROTOSTANE AND PROTOSTANE-TYPE TRITERPENES WITH VASORELAXANT EFFECTS FROM CHINESE ALISMATIS RHIZOMA
ABSOLUTE STEREOSTRUCTURES OF ALISMALACTONE 23-ACETATE AND ALISMAKETONE-A 23-ACETATE, NEW SECO-PROTOSTANE AND PROTOSTANE-TYPE TRITERPENES WITH VASORELAXANT EFFECTS FROM CHINESE ALISMATIS RHIZOMA
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泽泻中具有舒血管作用的23-乙酸泽泻酮和23-乙酸泽泻酮、新环原甾烷和原甾烷型三萜的绝对立体结构
DOI：
10.1248/cpb.45.756
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发表时间：
1997
影响因子：
1.7
通讯作者：
H. Matsuda
中科院分区：
文献类型：
--
作者：
M. Yoshikawa;T. Murakami;Akira Ikebata;A. Ishikado;N. Murakami;J. Yamahara;H. Matsuda
从福建产泽泻（AlismaorientaleJUZEP）的干燥根茎中分离得到新的具有生物活性的开环原甾烷和原甾烷型三萜化合物：泽泻内酯23-乙酸酯（Alismalactone 23-acetate）和泽泻内酯-A 23-乙酸酯（Alismaketone-A 23-acetate）。根据化学和物理化学证据确定了新三萜的绝对立体结构，其中包括与已知三萜泽泻醇B单乙酸酯的化学相关性。泽泻内酯23-乙酸酯和泽泻内酯-A 23-乙酸酯对高浓度K+引起的大鼠离体主动脉条收缩有抑制作用。
New bioactive seco-protostane and protostane-type triterpenes, alismalactone 23-acetate and alismaketone-A 23-acetate, were isolated from Chinese Alismatis Rhizoma originating from Fukien province, the dried rhizoma of Alisma orientale JUZEP. Absolute stereostructures of the new triterpenes were determined on the basis of chemical and physicochemical evidence, which included chemical correlations with the known triterpene alisol B monoacetate. Alismalactone 23-acetate and alismaketone-A 23 acetate were found to show inhibitory activity on the contractions induced by a high concentration of K+ in isolated aortic strips from rats.