Aggregate data meta-analysis with time-to-event outcomes
Aggregate data meta-analysis with time-to-event outcomes
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DOI：
10.1002/sim.1303
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发表时间：
2002-11-30
影响因子：
2
通讯作者：
Marson, AG
中科院分区：
文献类型：
--
作者：
Williamson, PR;Smith, CT;Marson, AG
在对具有至事件发生时间结局的随机对照试验进行荟萃分析时，可能需要对部分或全部纳入的研究采用汇总数据方法。期刊中生存分析报告的变化表明，没有一种单一的方法可以提取log（风险比）估计值。描述了改进先前提出的用于从存活曲线估计对数（HR）的方法的方法。这些方法也适用于寿命表。在治疗效果随时间变化且荟萃分析中的试验具有不同随访时间长度的情况下，异质性可能是明显的。为了评估风险比是否随时间变化，提出了几种测试方法并进行了比较。一项比较男性和女性脑瘫患者预期寿命的队列研究和一项比较两种抗癫痫药物（卡马西平和丙戊酸钠）的5项试验的系统评价用于说明。版权所有（C）2002约翰威利父子有限公司
In a meta-analysis of randomized controlled trials with time-to-event outcomes, an aggregate data approach may be required for some or all included studies. Variation in the reporting of survival analyses in journals suggests that no single method for extracting the log(hazard ratio) estimate will suffice. Methods are described which improve upon a previously proposed method for estimating the log(HR) from survival curves. These methods extend to life-tables. In the situation where the treatment effect varies over time and the trials in the meta-analysis have different lengths of follow-up, heterogeneity may be evident. In order to assess whether the hazard ratio changes with time, several tests are proposed and compared. A cohort study comparing life expectancy of males and females with cerebral palsy and a systematic review of five trials comparing two anti-epileptic drugs, carbamazepine and sodium valproate, are used for illustration. Copyright (C) 2002 John Wiley Sons, Ltd.