Electrospun gelatin-arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application
Electrospun gelatin-arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application
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DOI：
10.1080/00914037.2018.1482466
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发表时间：
2019-07-24
影响因子：
3.2
通讯作者：
Yang, Hu
中科院分区：
文献类型：
--
作者：
Aduba, Donald C., Jr.;An, Seon-Sook;Yang, Hu
将阿魏酸阿拉伯木聚糖（AXF）与明胶（GEL）以1：1、2：1和4：1的质量比共混，经静电纺丝制成复合纤维毡作为伤口愈合药物递送平台。复合纤维的形态，拉伸性能，孔径，孔隙率和分子组成方面进行了表征。复合纤维具有良好的细胞相容性。将银浸渍到GEL-AXF纳米纤维中，并缓慢释放，导致细菌生长抑制，如通过Kirby-Bauer圆盘扩散测定所证实的。这项工作建立了一个静电纺阿拉伯木聚糖纤维材料平台，具有治疗慢性糖尿病伤口的潜力。[图形]。
Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby-Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.[GRAPHICS].