Fatal outcome in a liver transplant recipient with COVID-19
Fatal outcome in a liver transplant recipient with COVID-19
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DOI：
10.1111/ajt.15909
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发表时间：
2020-05-04
影响因子：
8.8
通讯作者：
Zheng, Ming-Hua
中科院分区：
文献类型：
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作者：
Huang, Jiao-Feng;Zheng, Kenneth I.;Zheng, Ming-Hua
肝损伤在新冠肺炎患者中很常见，但对其临床表现和肝移植背景下的严重程度知之甚少。我们描述了一位3年前因肝细胞癌而接受肝移植的患者的新冠肺炎的病例。患者就诊时出现呼吸道疾病症状，咽拭子检出严重急性呼吸综合征冠状病毒2型。他的病情从轻微迅速发展到危重，并伴有几处医院感染和多器官衰竭。尽管进行了多次侵入性手术和抢救治疗，他还是死于这种疾病。新冠肺炎在移植后环境中的管理提出了复杂的挑战，强调了严格预防策略的重要性。
Liver injury is common in patients with COVID-19, but little is known about its clinical presentation and severity in the context of liver transplant. We describe a case of COVID-19 in a patient who underwent transplant 3 years ago for hepatocellular carcinoma. The patient came to clinic with symptoms of respiratory disease; pharyngeal swabs for severe acute respiratory syndrome coronavirus 2 were positive. His disease progressed rapidly from mild to critical illness and was complicated by several nosocomial infections and multiorgan failure. Despite multiple invasive procedures and rescue therapies, he died from the disease. The management of COVID-19 in the posttransplant setting presents complex challenges, emphasizing the importance of strict prevention strategies.