Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells
Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells
复制标题
前列腺素 D2 控制恶性黑色素瘤细胞的肺转移
作者：
D. Stringfellow;F. Fitzpatrick
Selective metastasis of malignant cells in various neoplastic processes is poorly understood. Metastasis seems to be associated with inherent biochemical and biological properties of tumour cells which guarantee their survival and multiplication. These properties may include surface enzymes1, interaction with various host defence systems and cells2–4, combination with host platelets5, or with the host endothelial cells, and adhesiveness of the metastatic cell. Fidler2,6,7 has developed a series of malignant melanoma cells that are useful for studying tumour metastasis. By comparing the moderate metastatic parent line, B16F1 to the highly metastatic Une, B16F10, it is possible to study metastasis selectively. Prostaglandins influence various cell functions, and may be involved in regulation of neoplastic processes8–10. We have recently reported that prostaglandin D2 (PGD2) formation by malignant melanoma cells in vitro is inversely correlated with their metastatic potential11. The studies we describe here were designed to determine whether treating the cells with a cyclooxygenase inhibitor, which would block conversion of arachidonic acid to prostaglandins, would affect the metastatic rate of either cell. The results suggest that PGD2 is involved in the metastasis of these cells.
