Mathematical optimization techniques in drug product design and process analysis.
Mathematical optimization techniques in drug product design and process analysis.
复制标题
药品设计和工艺分析中的数学优化技术。
DOI：
10.1002/jps.2600591110
复制
发表时间：
1970
期刊：
影响因子：
--
通讯作者：
Gilbert S. Banker
中科院分区：
文献类型：
--
作者：
Dale E. Fonner;James R. Buck;Gilbert S. Banker
优化技术代表了研究人员在寻找特定问题的最佳解决方案时可用的分析工具。已经开发出将典型的药物开发问题构建到一个框架中的方法，通过该框架可以采用复杂的数学技术来得出最佳解决方案。药品和工艺设计问题被构造为约束优化问题，随后通过拉格朗日优化方法求解。该优化方法用于生成典型片剂设计问题中的最佳配方，并确定典型封装设计问题中加工变量的优化水平。
Optimization techniques represent analytical tools available to the researcher in his search for the best possible solution to a particular problem. Methodologies have been developed for structuring typical pharmaceutical development problems into a framework whereby sophisticated mathematical techniques can be employed to arrive at an optimal solution. Pharmaceutical product and process design problems were structured as constrained optimization problems and subsequently solved by the Lagrangian method of optimization. This optimization method was employed to generate optimal formulations in typical tablet design problems and to locate optimizing levels of processing variables in a typical encapsulation design problem.