The effectiveness of influenza vaccination in preventing hospitalisations of elderly individuals in two influenza seasons: a multicentre case-control study, Spain, 2013/14 and 2014/15.
The effectiveness of influenza vaccination in preventing hospitalisations of elderly individuals in two influenza seasons: a multicentre case-control study, Spain, 2013/14 and 2014/15.
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DOI：
10.2807/1560-7917.es.2017.22.34.30602
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发表时间：
2017-08-24
期刊：
影响因子：
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通讯作者：
The Working Group Of The Project Pi/
中科院分区：
文献类型：
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作者：
Domínguez A;Soldevila N;Toledo D;Godoy P;Espejo E;Fernandez MA;Mayoral JM;Castilla J;Egurrola M;Tamames S;Astray J;Morales-Suárez-Varela M;The Working Group Of The Project Pi/
接种流感疫苗可以限制流感对社区的影响。本研究的目的是评估流感疫苗接种在预防西班牙≥ 65岁人群住院的有效性。在2013/14和2014/15期间，在20家西班牙医院进行了多中心病例对照研究。根据性别、年龄和住院日期，将年龄≥ 65岁的实验室确诊流感住院患者与对照组相匹配。通过多变量条件逻辑回归计算调整后的疫苗有效性（VE）。共有728例病例和1，826例匹配对照被纳入研究。总体VE为36%（95%置信区间（CI）：22-47）。无高危疾病的患者VE为51%（95%CI：15-71），有高危疾病的患者VE为30%（95%CI：14-44）。65-79岁患者的VE为39%（95% CI：20-53），≥ 80岁患者的VE为34%（95% CI：11-51），且对甲型（H1N1）pdm 09亚型的VE高于对甲型（H3 N2）亚型的VE。接种流感疫苗可有效防止老年人住院。
Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case–control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22–47). VE was 51% (95% CI: 15–71) in patients without high-risk medical conditions and 30% (95% CI: 14–44) in patients with them. VE was 39% (95% CI: 20–53) in patients aged 65–79 years and 34% (95% CI: 11–51) in patients aged ≥ 80 years, and was greater against the influenza A(H1N1)pdm09 subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals.