Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses
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DOI：
10.1172/jci22325
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发表时间：
2004-12-01
影响因子：
15.9
通讯作者：
Kim, CH
中科院分区：
文献类型：
--
作者：
Lim, HW;Hillsamer, P;Kim, CH
T细胞如何迁移到GC，以及它们是否调节GC中T细胞（GC-Th细胞）的辅助活性仍然知之甚少。我们在人扁桃体中发现了一个T细胞亚群，它对GC-Th细胞依赖的B细胞反应显示出有效的抑制活性。这些表面表型为CD 4（+）CD 25（+）CD 69（-）的T细胞迁移到CCL 19（一种在T细胞区中表达的趋化因子）很好，但迁移到CXCL 13（一种在B细胞区中表达的趋化因子）很差。这种向富含T细胞区的迁移在T细胞活化后迅速转变为向B细胞滤泡的运输。T细胞活化后趋化行为的这种变化与它们在2种趋化因子受体CXCR 5和CCR 7表达中的转换一致。CD 4（+）CD 25（+）CD 69（-）调节性T细胞抑制GC-Th细胞和GC-Th细胞诱导的B细胞反应，例如IG产生、存活和激活诱导的胞嘧啶脱氨酶的表达。我们的研究结果已经确定了一个子集的TCLs，这是生理相关的GC-Th细胞依赖的B细胞的反应和一个潜在的调节机制，这些TCLs的GC的贩运。
How Tregs migrate to GCs, and whether they regulate the helper activity of the T cells in GCs (GC-Th cells) remains poorly understood. We found a T cell subset in human tonsils that displays potent suppressive activities toward GC-Th cell-dependent B cell responses. These Tregs with the surface phenotype of CD4(+)CD25(+)CD69(-) migrate well to CCL19, a chemokine expressed in the T cell zone, but poorly to CXCL13, a chemokine expressed in the B cell zone. This migration toward the T cell-rich zone rapidly changes to trafficking toward B cell follicles upon T cell activation. This change in chemotactic behavior upon activation of T cells is consistent with their switch in the expression of the 2 chemokine receptors CXCR5 and CCR7. CD4(+)CD25(+)CD69(-) Tregs suppress GC-Th cells and GC-Th cell-induced B cell responses such as Ig production, survival, and expression of activation-induced cytosine deaminase. Our results have identified a subset of Tregs that is physiologically relevant to GC-Th cell-dependent B cell responses and a potential regulation mechanism for the trafficking of these Tregs to GCs.