Cutaneous adverse drug reactions seen at a university hospital department of dermatology
Cutaneous adverse drug reactions seen at a university hospital department of dermatology
复制标题
DOI：
10.2340/00015555-0153
复制
发表时间：
2006-01-01
影响因子：
3.6
通讯作者：
Bindslev-Jensen, Carsten
中科院分区：
文献类型：
--
作者：
Borch, Jakob E.;Andersen, Klaus E.;Bindslev-Jensen, Carsten
疑似皮肤药物不良反应的患者通常被转诊到过敏诊所或皮肤科进行评估。这些患者的选择与医院人群的前瞻性和横断面研究中确定的患者进行比较。这解释了观察到的特定反应和诱发药物的流行率的变化。本研究调查了皮肤药物不良反应的患病率在一所大学医院皮肤科，特别是专注于过敏。2003年4月至12月期间进行了为期8个月的调查。在此期间怀疑有皮肤药物不良反应的连续患者由皮肤科医生检查并进行调查。在纳入的194例患者中评估了药物可归因性; 33.5%的患者有一定或可能的药物可归因性。注射部位的荨麻疹和局部反应是最常见的反应（分别为25%和18.8%）。β-内酰胺类抗生素、脱敏提取物和胰岛素是涉及的主要药物组，分别占反应的22.8%、17.1%和14.2%。脱敏提取物和胰岛素引起的反应比预期的要多。这可能反映了转诊到过敏诊所的模式。
Patients with suspected cutaneous adverse drug reactions are often referred to allergy clinics or departments of dermatology for evaluation. These patients are selected compared with patients identified in prospective and cross-sectional studies of hospital populations. This explains the observed variation in prevalence of specific reactions and of eliciting drugs. This study investigated the prevalence of cutaneous adverse drug reactions in a university hospital department of dermatology that is specially focused on allergy. An 8-month survey was carried out during the period April-December 2003. Consecutive patients suspected of having cutaneous adverse drug reactions during this period were examined by dermatologists and investigated. Drug imputability was assessed in the 194 patients included; 33.5% had an exanthema with certain or likely drug imputability. Urticaria and local reactions at injection sites were the most frequent reactions (25% and 18.8%, respectively). beta-lactam antibiotics, extracts for desensitization and insulins were the main drug groups involved, and accounted for 22.8%, 17.1% and 14.2%, respectively, of the reactions. Extracts for desensitization and insulins elicited more reactions than expected. This probably reflects the referral pattern to an allergy clinic.