IMMUNOREGULATORY CELLS IN HUMAN DECIDUA - MORPHOLOGY, IMMUNOHISTOCHEMISTRY AND FUNCTION
IMMUNOREGULATORY CELLS IN HUMAN DECIDUA - MORPHOLOGY, IMMUNOHISTOCHEMISTRY AND FUNCTION
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DOI：
10.1051/rnd:19881006
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发表时间：
1988-01-01
期刊：
影响因子：
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通讯作者：
RITSON, A
中科院分区：
文献类型：
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作者：
BULMER, JN;PACE, D;RITSON, A
局部子宫内母胎免疫相互作用对正常妊娠可能很重要，这一建议导致了对蜕膜化子宫内膜免疫调节功能的研究。人类蜕膜是复杂的，细胞类型可能很难区分在光学显微镜水平。免疫组织化学技术允许抗原识别细胞内n蜕膜和丰富的白细胞存在于整个怀孕。巨噬细胞（CD14+）在整个妊娠期的底蜕膜和壁蜕膜中含量丰富，可能与绒毛外滋养细胞密切相关。II类MHC抗原和CD11c的表达可能提示免疫作用，但其溶酶体酶的含量可能指示吞噬功能。在早期人类蜕膜中发现抗原呈递能力，可能是由于巨噬细胞。由于分泌前列腺素E，蜕膜巨噬细胞也被认为具有免疫抑制功能。早孕期蜕膜颗粒淋巴细胞丰富，相当于所谓的子宫内膜间质粒细胞。它们表达CD2、CD7、CD38和NKH 1，但对经典T细胞和NK细胞标志物呈阴性，并且它们不表达IL 2受体。在标准NK测定中，半纯化的群体显示出低水平的细胞毒性。因此，免疫组织化学技术可以对人类蜕膜中潜在的免疫活性细胞进行表征。然而，它们在体外和体内的作用仍有待确定。
Suggestions that local intrauterine materno-fetal immune interactions may be important for normal pregnancy have led to investigation of immunoregulatory function by decidualised endometrium. Human decidua is complex and cell types may be difficult to distinguish at the light microscope level.Immunohistochemical techniques have allowed antigenic identification of cells within n decidua and abundant leucocytes are present throughout pregnancy. Macrophages (CD14+) are abundant in decidua basalis and decidua parietalis throughout pregnancy and may be closely associated with extravillous trophoblast. Expression of class II MHC antigens and CD11c may suggest an immunological role but their content of lysosomal enzymes could indicate phagocytic functions. Antigen-presenting capacity has been noted in early human decidua and may be due to macrophages. Decidual macrophages have also been attributed with immunosuppressive function due to secretion of prostaglandin E,. Decidual granulated lymphocytes are abundant in the first trimester and correspond to the so-called endometrial stromal granulocytes. They express CD2, CD7, CD38 and NKH1 but are negative for classical T cell and NK cell markers and they do not express the IL2 receptor. Semipurified populations show low levels of cytotoxicity in a standard NK assay. Thus, immunohistochemical techniques have allowed characterisation of potentially immunocompetent cells in human decidua. However, their roles both in vitro and in vivo remain to be established with certainty.