Nonuniform expression of a mouse mammary tumor virus-driven int-2/Fgf-3 transgene in pregnancy-responsive breast tumors.
Nonuniform expression of a mouse mammary tumor virus-driven int-2/Fgf-3 transgene in pregnancy-responsive breast tumors.
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小鼠乳腺肿瘤病毒驱动的 int-2/Fgf-3 转基因在妊娠反应性乳腺肿瘤中的不均匀表达。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
C. Dickson
中科院分区：
文献类型：
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作者：
G. Stamp;V. Fantl;R. Poulsom;S. Jamieson;R. Smith;G. Peters;C. Dickson
We have developed transgenic mice in which expression of the mouse int-2/Fgf-3 gene is regulated by a single long terminal repeat from mouse mammary tumor virus. Such mice contain and transmit a replica of the activated int-2/Fgf-3 allele present in a spontaneous mammary tumor from a BR6 mouse. Although free of infectious mouse mammary tumor virus and with a different genetic background, the transgenic mice develop pregnancy-responsive mammary epithelial proliferations that are similar to the early stages of tumorigenesis in the BR6 strain. Histological examination revealed that most of these tumors showed pronounced tubular and acinar structures, features usually associated with morphological differentiation. In some cases, the tumors were locally invasive, causing disruption of the dermis which manifested itself as local hair loss. In situ hybridization showed that patterns of transgene expression in the abnormal glands were markedly nonuniform. In contrast, mouse mammary tumor virus-induced neoplasms showed more uniform expression of int-2/Fgf-3, as did the urogenital epithelial proliferations that occur among males of this transgenic line. These data suggest that mammary tumors in virally infected animals may depend primarily on autocrine stimulation by the int-2/Fgf-3 gene product, whereas both autocrine and paracrine mechanisms may contribute to tumors and hyperplasias found in transgenic animals.
小鼠乳腺肿瘤病毒转化生长因子-α转基因小鼠的独特增生模式。
DOI：
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发表时间：
1992
期刊：
The American journal of pathology
影响因子：
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作者：
Halter,SA;Dempsey,P;Matsui,Y;Stokes,MK;Graves-Deal,R;Hogan,BL;Coffey,RJ
通讯作者：
Coffey,RJ
表达 MMTV/N-ras 癌基因的转基因小鼠的肿瘤发生和雄性不育。
影响因子：
8
作者：
Mangues,R;Seidman,I;Pellicer,A;Gordon,JW
通讯作者：
Gordon,JW