Effect of ethanol administration on cyclic 3',5'-adenosine monophosphate metabolism in brain.
Effect of ethanol administration on cyclic 3',5'-adenosine monophosphate metabolism in brain.
复制标题
乙醇给药对脑中环状 3,5-单磷酸腺苷代谢的影响。
DOI：
10.1016/0006-2952(73)90160-3
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发表时间：
1973
影响因子：
5.8
通讯作者：
M. A. Israel
中科院分区：
文献类型：
--
作者：
K. Kuriyama;M. A. Israel
环腺苷酸（cAMP）已被确定为许多胺和多肽酶3作用的细胞内介质，并可能在中枢神经系统的功能中起重要作用。4* 5虽然已经表明乙醇会引起内分泌系统功能的改变6 s7和脑中生物胺的代谢，* 但关于乙醇引起脑中环腺苷酸代谢变化的信息很少。在这份报告中，我们描述了慢性和急性给药乙醇对脑中环腺苷酸代谢的影响。在所有实验中使用了体重25-30 g的瑞士雌性白化病小鼠。连续给小鼠喂食流质饮食以研究长期乙醇给药的影响。如前所述，乙醇处理的动物接受61 μ g市售Metrecal、6%（w/v）乙醇和蒸馏水的饮食。7-9对照组接受与实验小鼠乙醇摄入量完全相同的含蔗糖等热量的液体饮食。每只小鼠含6%乙醇的流质饮食的平均日摄入量为7-9 ml，乙醇处理动物的每日乙醇剂量为16-21 g/kg体重。在完全相同的处理和环境条件下，将乙醇处理组和对照组中的动物保持在30”。在研究乙醇给药急性效应的实验中，用腹膜内注射乙醇（4 g/kg体重）或等热量蔗糖处理小鼠。
CYCLIC 3’, 5’-adenosine monophosphate (cyclic AMP) has been established as an intracellular mediator of the action of a number of amines and polypeptide hormones’-3 and may play an important role in the function of the central nervous system. 4* 5 Although it has been shown that ethanol induces alterations in the function of the endocrine system6s7 and the metabolism of biogenic amines in the brain,* little information is available concerning ethanol induced changes in the metabolism of cyclic AMP in the brain. In this report we describe the effects of chronic and acute administration of ethanol on cyclic AMP metabolism in the brain.Swiss female albino mice weighing 25-30 g were used in all experiments. Mice were fed continuously with a liquid diet to study the effect of chronic ethanol administration. Ethanol treated animals received a diet of 61 y0 commercial Metrecal, 6%(w/v) ethanol, and distilled water as previously described. 7-9 Control groups received exactly the same amount of liquid diet containing sucrose isocaloric to the ethanol intake in the experimental mice. The average daily intake per mouse of liquid diet containing 6% ethanol was 7-9 ml, a daily ethanol dose of 16-21 g/kg body wt in the ethanol treated animals. Animals in both the ethanol treated and control groups were maintained at 30” under exactly the same handling and environmental conditions. Mice were treated with an intraperitoneal injection of ethanol (4 g/kg body wt) or isocaloric sucrose in experiments in which the acute effects of ethanol administration were studied.