The flow of cytometry into systems biology
The flow of cytometry into systems biology
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DOI：
10.1093/bfgp/elm011
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发表时间：
2007-06-01
期刊：
影响因子：
--
通讯作者：
Yang, Loretta
中科院分区：
文献类型：
--
作者：
Nolan, John P.;Yang, Loretta
生物医学研究正在发展，以解决生物系统的分子途径整合到复杂的网络。分子和细胞分析工具也在不断发展，以应对这种方法的新挑战和机遇。流式细胞术是一种通用的分析平台，能够高速定量测量细胞和其他颗粒。基因组学、蛋白质组学和系统生物学的进步带来了机会，这些能力正在一系列新的应用中得到利用和扩展，这些新的应用反过来又影响着临床诊断、疫苗开发和药物发现。在这篇综述中，我们强调了其中的一些进展，并考虑流式细胞术技术的未来发展。
Biomedical research is evolving to address biological systems as molecular pathways integrated into complex networks. Tools for molecular and cell analysis are also evolving to address the new challenges and opportunities of this approach. Flow cytometry is a versatile analytical platform, capable of high speed quantitative measurements of cells and other particles. These capabilities are being exploited and extended in a range of new applications stemming from opportunities presented by the advances of genomics, proteomics and systems biology, which are in turn impacting clinical diagnosis, vaccine development and drug discovery. In this review, we highlight some of these advances and consider the future evolution of flow cytometry technology.