The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand.
The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand.
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DOI：
10.1084/jem.185.6.1101
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发表时间：
1997-03-17
期刊：
影响因子：
--
通讯作者：
Liu YJ
中科院分区：
文献类型：
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作者：
Grouard G;Rissoan MC;Filgueira L;Durand I;Banchereau J;Liu YJ
最近发现CD_4+CD_(11)c、−、CD_3、−血细胞亚群在单核细胞条件培养液中可发育为树突状细胞。在这里，我们证明了从扁桃体中分离出来的CD4+CD11c−CD3−细胞对应于所谓的浆细胞样T细胞，这是一种长期被病理学家在次级淋巴组织中观察到的鲜为人知的细胞类型。它们表达CD45RA，但不表达已知淋巴或髓系细胞类型的特异性标记。除非被IL-3挽救，否则它们在培养中会经历快速的凋亡。CD40配体的进一步加入导致它们分化为树突状细胞，表达低水平的髓系抗原CD13和CD33。
A subset of CD4+CD11c−CD3− blood cells was recently shown to develop into dendritic cells when cultured with monocyte conditioned medium. Here, we demonstrate that CD4+ CD11c−CD3− cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that has long been observed by pathologists within secondary lymphoid tissues. They express CD45RA, but not markers specific for known lymphoid- or myeloid-derived cell types. They undergo rapid apoptosis in culture, unless rescued by IL-3. Further addition of CD40-ligand results in their differentiation into dendritic cells that express low levels of myeloid antigens CD13 and CD33.