Impact of cytomegalovirus reactivation on clinical outcomes in immunocompetent critically ill patients: protocol for a systematic review and meta-analysis.
Impact of cytomegalovirus reactivation on clinical outcomes in immunocompetent critically ill patients: protocol for a systematic review and meta-analysis.
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DOI：
10.1186/s13643-016-0303-8
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发表时间：
2016-07-28
影响因子：
3.7
通讯作者：
Sligl W
中科院分区：
文献类型：
--
作者：
Lachance P;Chen J;Featherstone R;Sligl W
重症患者巨细胞病毒（CMV）再激活是一种公认的现象，发生率高达71%。许多研究调查了CMV再激活与危重患者结局之间的相关性，结果相互矛盾。我们建议进行一项系统性综述和荟萃分析，以确定巨细胞病毒再激活对以患者为中心的结果和免疫功能正常的重症患者的卫生资源利用措施的影响。将与一名研究图书管理员协商，制定一项搜索战略，并建立电子数据库（即，将检索奥维德MEDLINE、奥维德EMBASE和科克伦图书馆（包括科克伦系统评价数据库、科克伦对照试验中心注册库（CENTRAL））中的原始研究。将手动检索选定的灰色文献来源。检索主题将包括巨细胞病毒、重症监护室和脓毒症。引文筛选、选择、质量评估和数据提取将一式两份进行。将描述巨细胞病毒再激活对选定的以患者为中心的结局和卫生资源利用措施的影响的合并效应估计。本系统综述旨在探讨免疫功能正常的危重患者中CMV再激活对以患者为中心的结局和卫生资源利用的影响。我们的研究结果将有助于更好地确定与CMV再激活相关的疾病负担。事实上，迄今为止的证据表明，该患者人群的死亡率增加。然而，巨细胞病毒再激活和卫生资源利用之间的关系仍然不太清楚。根据我们的研究结果，未来可能需要研究CMV治疗或预防对结局（包括死亡率以外的结局）的影响。PROSPERO CRD 42016035446本文的在线版本（doi：10.1186/s13643-016-0303-8）包含补充材料，可供授权用户使用。
Cytomegalovirus (CMV) reactivation in critically ill patients is a well-recognized phenomenon with an incidence as high as 71 %. A number of studies have investigated the association between CMV reactivation and outcomes in critically ill patients with conflicting results. We propose to conduct a systematic review and meta-analysis to determine the impact of CMV reactivation on patient-centered outcomes and measures of health resource utilization in immunocompetent critically ill patients. In consultation with a research librarian, a search strategy will be developed and electronic databases (i.e., Ovid MEDLINE, Ovid EMBASE, and the Cochrane Library including the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials (CENTRAL)) will be searched for original studies. Selected grey literature sources will be hand-searched. Search themes will include cytomegalovirus, intensive care unit, and sepsis. Citation screening, selection, quality assessment, and data abstraction will be performed in duplicate. Pooled effect estimates of the impact of CMV reactivation on selected patient-centered outcomes and measures of health resource utilization will be described. This systematic review aims to explore the impact of CMV reactivation on patient-centered outcomes and health resource utilization in immunocompetent critically ill patients. Our results will help to better define the burden of disease associated with CMV reactivation. Indeed, evidence to date suggests increased mortality in this patient population. However, the relationship between CMV reactivation and health resource utilization remains less clear. Based on our results, future study on the impact of CMV treatment or prophylaxis on outcomes (including those other than mortality) may be warranted. PROSPERO CRD42016035446 The online version of this article (doi:10.1186/s13643-016-0303-8) contains supplementary material, which is available to authorized users.