ASSOCIATION OF TUBERCULOSIS AND M-TUBERCULOSIS-SPECIFIC ANTIBODY-LEVELS WITH HLA
ASSOCIATION OF TUBERCULOSIS AND M-TUBERCULOSIS-SPECIFIC ANTIBODY-LEVELS WITH HLA
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DOI：
10.1093/infdis/159.3.549
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发表时间：
1989-03-01
影响因子：
6.4
通讯作者：
IVANYI, J
中科院分区：
文献类型：
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作者：
BOTHAMLEY, GH;BECK, JS;IVANYI, J
在寻找控制结核病易感性的HLA连锁免疫反应基因时，我们对来自印度尼西亚泗水的101例痰涂片阳性肺结核患者和64例健康对照者进行了HLA分型，并测量了明确定义的结核分枝杆菌抗原决定簇的抗体滴度。HLA-DR 2和DQw 1与痰涂片阳性肺结核相关（归因风险分别为36%和39%），而DQw 3与对照组的相关性更强（预防分数为57%）。仅存在于结核杆菌上的38 kDa蛋白的TB 71和TB 72表位的抗体滴度与DR 2强烈相关（Pcorr分别= 0.001和0.024）。该疾病与对M的38-kDa抗原的抗体应答的关联。具有II类HLA基因HLA-DR 2的结核病表明Ir基因介导的对该抗原的免疫应答的调节可能对痰涂片阳性结核病的发展具有致病意义。
In the search for HLA-linked immune response genes that control susceptibility to tuberculosis, we performed HLA typing and measured antibody titers to well-defined Mycobacterium tuberculosis antigenic determinants in 101 patients with sputum smear-positive pulmonary tuberculosis and 64 healthy controls from Surabaya, Indonesia. HLA-DR2 and DQw1 were associated with sputum smear-positive pulmonary tuberculosis (attributable risk - 36% and 39%, respectively), while DQw3 was associated even more strongly with the control group (preventive fraction - 57%). Antibody titers to the TB71 and TB72 epitopes of the 38-kDa protein, present only on tubercle bacilli, were strongly associated with DR2 (Pcorr = 0.001 and 0.024 respectively). The association of both the disease and the antibody response to the 38-kDa antigen of M. tuberculosis with Class II HLA genes HLA-DR2 indicates that Ir-gene-mediated regulation of the immune response to this antigen may be of pathogenic significance for the development of sputum smear-positive tuberculosis.